Table 1 Most relevant miRNAs in cancer

miR-15a

Multiple Myeloma

BCL2, MYB, MYC, KRAS, CCND1, CDC25A, ERBB2, TP53, PTEN, ITGA2, VEGFA,RAB21, CADM1, DICER1

Oncogene Inhibition, Cell Cycle Control, Inhibition of Angiogenesis

[97-100]

miR-34a

Breast, Prostate, Bladder, and Brain Cancer

BCL2, MYC, MET, MEK1, E2F3, CDK4, CDK6, CD44

Cell Cycle Control, Apoptosis, Senescence, Angiogenesis

[116,117,118]

let-7 family

Breast, Colon, Gastric, Liver, Lung, Prostate, Ovarian Cancer, Chronic Myelogenous Leukemia, B Cell Lymphoma

NF2, HRAS, KRAS, NRAS, LIN28, MYC, DICER1, HMGA2, CASP3

Oncogene Inhibition, Cell Cycle Control, Cancer Stem Cell Regulation

[72,119-124,125]

miR-21

Ovarian, Lung, and Colon Carcinoma, Pancreatic and Breast Cancer

TPM1, NFIB, PDCD4, CDKN1A, FAS, TIMP3, SOX5, PTEN, BMPR2

Promotion of Cancer Cell Proliferation, Survival and Migration

[79-83,126-128]

miR-17-92 cluster

Leukemia

DICER, PTEN, E2F1, E2F2, E2F3, CDKN1A, PTEN, BCL2, CCND1, BMPR2, HOXA9

Induction of Angiogenesis, Enhance Endothelial Cell Migration

[94,129]

miR-494

Small Cell Lung Carcinoma, Breast Cancer

PTEN, CDH17, MAL

Inhibition of Apoptosis, Induction of Chemoresistance, Cell Adhesion

[89,130]

miR-210

Breast Cancer, Renal, Prostate, and Pancreatic Cancer, Lymphoma

MYC, STAT5A, HIF1A, TP53, E2F3, VEGFA, EGFR, CDKN1A, AKT1, DICER1, PTEN, CDKN1B, ERBB2, CD40, BCL2, CASP8AP2, KRAS, NOTCH1

Metastasis, Angiogenesis, Hypoxia, Tumorigenesis

[7,96,131-133]

miR-200 family

Breast Cancer

ZEB1, ZEB2, SIP1, CCND1, CDC25C, MYC, MYCN, PTEN, SIRT1, VEGFA, MET, CDKN1B, TP53, PROM1, EGFR, CD44

Tumorigenesis and Tumor Progression, Metastasis, Invasion

[92,93]

miR-9

Melanoma, Glioblastoma, Neuroblastoma

MYC, MYCN,VEGFA, MMP9, CDH1

Metastasis, Drug Resistance, Angiogenesis

[95,110,134,135]

miR-221/miR-222

Breast, Colorectal, Renal, Pancreatic, and Ovarian Cancer, Melanoma, Glioblastoma, Leukemia

KIT, PTEN, CDKN1A, CDKN1B, KRAS, DICER1, MMP1

Drug Resistance, Metastasis, Invasion, Cell Growth

[108,136-143]

miR-23b

Breast, Renal, Pancreatic, Bladder, and Prostate Cancer Thymic Lymphoma

VHL, PTEN, FAS, NISCARI, PAK2, ATG12, ZEB1, SRC, AKT

Cell Proliferation, Chemoresistance, Inhibition of Invasion and Angiogenesis

[73,75]

miR-542-3p

Pancreatic, and Cervical Carcinoma, Neuroblastoma, Colon Cancer

CDH17, TRAF4, ANGPT2, ILK, SURVIVIN

Decreased Cell Adhesion, Induction of Apoptosis, Inhibition of Proliferation and Angiogenesis

[89,144,145]

miR-125b

Breast, and Liver Cancer

LIN28B, CCND1, SOX2, MYC, CDK6,

Increase Drug Resistance, Decreased in Resistant Cells, Inhibits Cell Proliferation

[146-149]

miR-105

Breast, Ovarian, Gastric, and Prostate Cancer, Glioma, Hepatocellular Carcinoma

TJP1 DNTT, PCNA, BAX, CCND1, CDK6

Regulation of Migration, Metastasis, Proliferation, Apoptosis

[91,150-153]

miR-29

Breast, Lung, and Cervical Cancer, Neuroblastoma, B Cell Chronic and Acute Myeloid Leukemia

BACE1, DNMT3A, DNMT3B, CDC42, CDK6, TGFB3, IFNG

Modulation of Immune Response, Tumor Growth and Metastasis, Tumor Suppressor Function

[85,154-156]