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Table 1 Most relevant miRNAs in cancer

From: Signaling by exosomal microRNAs in cancer

miRNA Tumor Main target genes Function Reference
miR-15a Multiple Myeloma BCL2, MYB, MYC, KRAS, CCND1, CDC25A, ERBB2, TP53, PTEN, ITGA2, VEGFA,RAB21, CADM1, DICER1 Oncogene Inhibition, Cell Cycle Control, Inhibition of Angiogenesis [97-100]
miR-34a Breast, Prostate, Bladder, and Brain Cancer BCL2, MYC, MET, MEK1, E2F3, CDK4, CDK6, CD44 Cell Cycle Control, Apoptosis, Senescence, Angiogenesis [116,117,118]
let-7 family Breast, Colon, Gastric, Liver, Lung, Prostate, Ovarian Cancer, Chronic Myelogenous Leukemia, B Cell Lymphoma NF2, HRAS, KRAS, NRAS, LIN28, MYC, DICER1, HMGA2, CASP3 Oncogene Inhibition, Cell Cycle Control, Cancer Stem Cell Regulation [72,119-124,125]
miR-21 Ovarian, Lung, and Colon Carcinoma, Pancreatic and Breast Cancer TPM1, NFIB, PDCD4, CDKN1A, FAS, TIMP3, SOX5, PTEN, BMPR2 Promotion of Cancer Cell Proliferation, Survival and Migration [79-83,126-128]
miR-17-92 cluster Leukemia DICER, PTEN, E2F1, E2F2, E2F3, CDKN1A, PTEN, BCL2, CCND1, BMPR2, HOXA9 Induction of Angiogenesis, Enhance Endothelial Cell Migration [94,129]
miR-494 Small Cell Lung Carcinoma, Breast Cancer PTEN, CDH17, MAL Inhibition of Apoptosis, Induction of Chemoresistance, Cell Adhesion [89,130]
miR-210 Breast Cancer, Renal, Prostate, and Pancreatic Cancer, Lymphoma MYC, STAT5A, HIF1A, TP53, E2F3, VEGFA, EGFR, CDKN1A, AKT1, DICER1, PTEN, CDKN1B, ERBB2, CD40, BCL2, CASP8AP2, KRAS, NOTCH1 Metastasis, Angiogenesis, Hypoxia, Tumorigenesis [7,96,131-133]
miR-200 family Breast Cancer ZEB1, ZEB2, SIP1, CCND1, CDC25C, MYC, MYCN, PTEN, SIRT1, VEGFA, MET, CDKN1B, TP53, PROM1, EGFR, CD44 Tumorigenesis and Tumor Progression, Metastasis, Invasion [92,93]
miR-9 Melanoma, Glioblastoma, Neuroblastoma MYC, MYCN,VEGFA, MMP9, CDH1 Metastasis, Drug Resistance, Angiogenesis [95,110,134,135]
miR-221/miR-222 Breast, Colorectal, Renal, Pancreatic, and Ovarian Cancer, Melanoma, Glioblastoma, Leukemia KIT, PTEN, CDKN1A, CDKN1B, KRAS, DICER1, MMP1 Drug Resistance, Metastasis, Invasion, Cell Growth [108,136-143]
miR-23b Breast, Renal, Pancreatic, Bladder, and Prostate Cancer Thymic Lymphoma VHL, PTEN, FAS, NISCARI, PAK2, ATG12, ZEB1, SRC, AKT Cell Proliferation, Chemoresistance, Inhibition of Invasion and Angiogenesis [73,75]
miR-542-3p Pancreatic, and Cervical Carcinoma, Neuroblastoma, Colon Cancer CDH17, TRAF4, ANGPT2, ILK, SURVIVIN Decreased Cell Adhesion, Induction of Apoptosis, Inhibition of Proliferation and Angiogenesis [89,144,145]
miR-125b Breast, and Liver Cancer LIN28B, CCND1, SOX2, MYC, CDK6, Increase Drug Resistance, Decreased in Resistant Cells, Inhibits Cell Proliferation [146-149]
miR-105 Breast, Ovarian, Gastric, and Prostate Cancer, Glioma, Hepatocellular Carcinoma TJP1 DNTT, PCNA, BAX, CCND1, CDK6 Regulation of Migration, Metastasis, Proliferation, Apoptosis [91,150-153]
miR-29 Breast, Lung, and Cervical Cancer, Neuroblastoma, B Cell Chronic and Acute Myeloid Leukemia BACE1, DNMT3A, DNMT3B, CDC42, CDK6, TGFB3, IFNG Modulation of Immune Response, Tumor Growth and Metastasis, Tumor Suppressor Function [85,154-156]