Immunohistochemical staining in adjacent normal mucosa and gastric cancer tissues. A and B were adjacent normal mucosa while C,D,E and F were gastric cancer tissues within which E and F were from patient who simultaneously suffered gastric cancer and obesity. The original tissues of C—F were evaluated to be grade I tumor according to the 3rd Japanese classification of gastric carcinoma. C and D were considered to be diffuse type in Lauren Classification of gastric cancer whereas E and F were intestinal type. The follow-up was showed by graph G within which the red foldline stands for gastric cancer & obesity group and the green one represents gastric cancer group.