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Table 1 Relationship between FoxM1 expression from IHC and clinicopathological factors of 87 CRC patients

From: Short hairpin RNA- mediated gene knockdown of FOXM1 inhibits the proliferation and metastasis of human colon cancer cells through reversal of epithelial-to-mesenchymal transformation

Clinic parameters

Total

FoxM1 expression

χ 2

P value

None or low

High

Age(years)

T=87

N=35(40.2%)

N=52(59.8%)

  

<65

33(37.9%)

15(45.5%)

18(54.5%)

0.604

0.437

>=65

54(62.1%)

20(37.0%)

34(63.0%)

  

Gender

     

Male

42(48.3%)

19(45.2%)

23(54.8%)

0.847

0.357

Female

45(51.7%)

16(35.6%)

29(64.4%)

  

Tumor size

     

<5cm

56(64.4%)

20(35.7%)

36(64.3%)

1.333

0.248

>=5cm

31(35.6%)

15(48.4%)

16(51.6%)

  

Tumor location

     

Right colon

33(37.9%)

11(33.3%)

22(66.7%)

1.052

0.305

Left colon and rectum

54(62.1%)

24(44.4%)

30(55.6%)

  

TNM Stage

     

Stage I/II

42(48.3%)

19(45.2%)

23(54.8%)

0.847

0.357

Stage III/IV

45(51.7%)

16(35.6%)

29(64.4%)

  

Histological differentiation

     

Well

28(32.2%)

12(42.9%)

16(57.1%)

1.873

0.392

Moderate

46(52.9%)

20(43.5%)

26(56.5%)

  

Poor

13(14.9%)

3(23.1%)

10(76.9%)

  

Lymph node metastasis

     

Yes

47(54.0%)

12(25.5%)

35(74.5%)

9.184

0.002***

No

40(56.0%)

23(57.5%)

17(42.5%)

  

Tumor recurrence

     

Yes

53(60.9%)

15(28.3%)

38(71.7%)

8.025

0.005***

No

34(39.1%)

20(58.8%)

14(41.2%)

  
  1. ***P < 0.001.