The relevance of cell type- and tumor zone-specific VEGFR-2 activation in locally advanced colon cancer

Table 4 Percentage distribution and statistical significance of VEGFR-2 and pVEGFR-2 in tumor cells of CC tissue

	Score	N0/M0	N+	M+	CC
		%	%	%	%
Tumor center
VEGFR-2	0	47	46	46	46
	1	39	46	50	54
	2	14	8	4	54
Cytoplasmatic VEGFR-2^Tyr1175	0	36	29	43	36
	1	14	17	14	64
	2	50	54	43	64
Nuclear VEGFR-2^Tyr1175	-	6	4	4	5
Nuclear VEGFR-2^Tyr1175	+	94	96	96	95
Cytoplasmatic VEGFR-2^Tyr1214	0	26	26	8	20
	1	31	26	29	80
	2	43	48	63	80
Nuclear VEGFR-2^Tyr1214	-	31	26	50	36
	+	69	74	50	64
Tumor budding
VEGFR-2	0	41	50	43	45
	1	48	10	43	55
	2	11	40	14	55
Cytoplasmatic VEGFR-2^Tyr1175	0	33	30	36	33
	1	15	5	14	67
	2	52	65	50	67
Nuclear VEGFR-2^Tyr1175	-	4	5	0	3
Nuclear VEGFR-2^Tyr1175	+	96	95	100	97
Cytoplasmatic VEGFR-2^Tyr1214	0	11	21	0	11
	1	22	26	17	89
	2	67	53	83	89
Nuclear VEGFR-2^Tyr1214	-	36	21	61	38
Nuclear VEGFR-2^Tyr1214	+	67	79	39	62

The intensity of the tumoral staining was scored on a semiquantitative scale from 0 to 2 for the investigated biomolecule (0: no staining, 1: weak staining, 2: strong staining). For the statistical analysis using Fisher’s exact test the examined cases were separated into two groups characterized by a negative/positive expression for VEGFR-2, VEGFR-2^Tyr1175 and VEGFR-2^Tyr1214. The line in the staining intensity column indicates this dichotomization for each biomolecule. There were no significant differences between the groups

ISSN: 1756-9966