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Table 4 Percentage distribution and statistical significance of VEGFR-2 and pVEGFR-2 in tumor cells of CC tissue

From: The relevance of cell type- and tumor zone-specific VEGFR-2 activation in locally advanced colon cancer

  Score N0/M0 N+ M+ CC
  % % % %
Tumor center
VEGFR-2 0 47 46 46 46
1 39 46 50 54
2 14 8 4
Cytoplasmatic VEGFR-2Tyr1175 0 36 29 43 36
1 14 17 14 64
2 50 54 43
Nuclear VEGFR-2Tyr1175 - 6 4 4 5
+ 94 96 96 95
Cytoplasmatic VEGFR-2Tyr1214 0 26 26 8 20
1 31 26 29 80
2 43 48 63
Nuclear VEGFR-2Tyr1214 - 31 26 50 36
  + 69 74 50 64
Tumor budding
VEGFR-2 0 41 50 43 45
1 48 10 43 55
2 11 40 14
Cytoplasmatic VEGFR-2Tyr1175 0 33 30 36 33
1 15 5 14 67
2 52 65 50
Nuclear VEGFR-2Tyr1175 - 4 5 0 3
+ 96 95 100 97
Cytoplasmatic VEGFR-2Tyr1214 0 11 21 0 11
1 22 26 17 89
2 67 53 83
Nuclear VEGFR-2Tyr1214 - 36 21 61 38
+ 67 79 39 62
  1. The intensity of the tumoral staining was scored on a semiquantitative scale from 0 to 2 for the investigated biomolecule (0: no staining, 1: weak staining, 2: strong staining). For the statistical analysis using Fisher’s exact test the examined cases were separated into two groups characterized by a negative/positive expression for VEGFR-2, VEGFR-2Tyr1175 and VEGFR-2Tyr1214. The line in the staining intensity column indicates this dichotomization for each biomolecule. There were no significant differences between the groups