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Table 7 Numerical and percentage distribution of ligand/VEGFR-2 and VEGFR-2/pVEGFR-2 co-expression in the vasculature

From: The relevance of cell type- and tumor zone-specific VEGFR-2 activation in locally advanced colon cancer

 

N0/M0

N+

M+

n (%)

n (%)

n (%)

VEGF-C+/VEGFR-2+

   

Capillaries

zone 1

20/8 (40)

9/6 (67)

9/6 (67)

zone 2

16/16 (100)

11/11 (100)

11/9 (82)

zone 3

18/11 (61)

13/11 (85)

16/14 (88)

Small vessels

zone 1

16/12 (75)

11/6 (55)

15/8 (53)

zone 2

23/21 (91)

16/15 (94)

17/14 (82)

zone 3

17/9 (53)

14/8 (57)

13/7 (54)

VEGF-D+/VEGFR-2+

   

Capillaries

zone 1

11/10 (91)

8/7 (88)

9/8 (89)

zone 2

19/19 (100)

11/11 (100)

15/14 (93)

zone 3

21/15 (71)

14/12 (86)

12/12 (100)

Small vessels

zone 1

10/9 (90)

6/4 (67)

8/5 (63)

zone 2

27/24 (89)

17/16 (94)

19/17 (89)

zone 3

26/16 (62)

19/11 (58)

15/10 (67)

VEGFR-2+/VEGFR-2 Tyr1175 +

   

Capillaries

zone 1

20/17 (85)

14/14 (100)

12/10 (83)

zone 2

34/31 (91)

21/19 (90)

18/15 (83)

zone 3

22/22 (100)

18/17 (94)

19/18 (95)

Small vessels

zone 1

13/10 (77)

8/8 (100)

11/9 (82)

zone 2

29/26 (90)

20/18 (90)

16/14 (88)

zone 3

18/16 (89)

12/12 (100)

9/8 (89)

VEGFR-2+/VEGFR-2 Tyr1214 +

   

Capillaries

zone 1

19/18 (95)

13/10 (77)

14/13 (93)

zone 2

33/32 (97)

21/19 (90)

21/21 (100)

zone 3

21/21 (100)

15/15 (100)

21/21 (100)

Small vessels

zone 1

15/14 (93)

8/6 (75)

11/10 (91)

zone 2

27/27 (100)

20/19 (95)

19/19 (100)

zone 3

17/17 (100)

12/11 (92)

12/12 (100)

  1. n: total number of ligand positive cases / total number of ligand positive cases with concomitant VEGFR-2 positivity or total number of VEGFR-2 positive cases / total number of VEGFR-2 positive cases with concomitant pVEGFR-2 positivity. There were no significant differences between the groups