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Table 4 Subgroup analyses of the relationships between Nestin expression and overall survival or progression-free-survival

From: Do relevant markers of cancer stem cells CD133 and Nestin indicate a poor prognosis in glioma patients? A systematic review and meta-analysis

Comparison variables

Overall survival

Progression-free survival

Number of studies, Heterogeneity (I2 statistics; %)

HR 95 % CI, P value

Interaction, P value

Number of studies, Heterogeneity (I2 statistics; %)

HR 95 % CI, P value

Interaction, P value

Total

8 (75.8)

1.75 (1.19–2.58), 0.004

NA

5 (71.5)

1.55 (0.96–2.51), 0.074

NA

Origin country

      

Europe

5 (73.1)

1.52 (1.04–2.21), 0.029

0.014

4 (74.1)

1.76 (0.98–3.14), 0.057

0.142

Asian

2 (81.8)

1.92 (0.43–8.62), 0.393

 

1 (NA)

1.55 (0.96–2.51), 0.973

 

USA

1 (NA)

13.42 (2.56–70.34), 0.002

    

Sample size

      

>50

5 (71.6)

1.41 (1.00–1.98), 0.051

0.005

3 (82.6)

1.39 (0.77–2.50), 0.277

0.322

≤50

3 (71.2)

3.61 (0.99–13.17), 0.052

 

2 (36.5)

2.14 (0.85–5.35), 0.105

 

Follow up period

      

1,>media 12months

2 (68.7)

4.96 (1.08–22.78), 0.040

0.001

1 (NA)

2.40 (1.60–3.40), 0.000

0.008

2,≤media 12months

3 (68.8)

1.64 (0.74–3.67), 0.225

 

3 (55.4)

1.49 (0.76–2.94), 0.246

 

3,No Referreed

3 (66.8)

1.35 (0.77–2.38), 0.300

 

1 (NA)

1.01 (0.57–1.79), 0.973

 

Median/mean age y

      

Referred

3 (83.4)

3.36 (0.72–15.61), 0.123

0.154

1 (NA)

1.01 (0.57–1.80), 0.973

0.142

No Referred

5 (75.8)

1.52 (1.04–2.21), 0.029

 

4 (74.7)

1.76 (0.98–3.14), 0.057

 

Test method

      

IHC

5 (82.1)

2.11 (1.10–4.04), 0.025

0.671

2 (83.6)

1.60 (0.69–3.73), 0.275

0.063

Others

3 (68.8)

1.64 (0.74–3.67), 0.225

 

3 (55.4)

1.49 (0.76–2.51), 0.246

 

Cut‑off level

      

1:median

5 (74.1)

1.55 (1.00–2.42), 0.050

0.021

3 (55.4)

1.49 (0.76–2.94), 0.246

0.063

2:others

3 (75.6)

2.10 (0.88–5.00), 0.093

 

2 (83.6)

1.60 (0.69–3.73), 0.275

 

WHO grade

      

IV

2 (0.0)

1.09 (0.83–1.44), 0.518

0.000

2 (0.00)

1.04 (0.77–1.41), 0.808

0.000

II–III

4 (57.2)

3.11 (1.45–6.67), 0.004

 

3 (0.00)

2.34 (1.68–3.27), 0.000