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Table 3 Correlation of clinicopathologic parameters with HMGB1, CC3, Ki6 and RAGE expressions

From: Increased HMGB1 and cleaved caspase-3 stimulate the proliferation of tumor cells and are correlated with the poor prognosis in colorectal cancer

 

HMGB1 + (%)

p

CC3 + (%)

p

Ki67 + (%)

p

RAGE+(%)

p

Sex

 

0.964

 

0.081

 

0.121

 

0.524

Male

17(43.59)

 

14(35.90)

 

22(56.41)

 

26(66.67)

 

female

15(44.12)

 

6(17.65)

 

13(38.24)

 

25(73.53)

 

Age

 

0.684

 

0.138

 

0.769

 

0.589

≤70 y

14(46.67)

 

11(36.67)

 

15(50)

 

22(73.33)

 

>70 y

18(41.86)

 

9(20.93)

 

20(46.51)

 

29(67.44)

 

TNM stage

 

0.496

 

0.007*

 

0.321

 

0.03*

Stage I

3(60)

 

2(40)

 

2(40)

 

1(20)

 

Stage II

14(41.18)

 

7(20.59)

 

13(38.24)

 

22(64.71)

 

Stage III

12(40)

 

7(20.59)

 

17(56.67)

 

25(83.33)

 

Stage IV

3(75)

 

4(100)

 

3(75)

 

3(75)

 

Lymphnodes

 

0.565

 

0.551

 

0.007*

 

0.050*

Negative

15(40.54)

 

9(24.32)

 

12(32.43)

 

22(59.46)

 

Positive

17(47.22)

 

11(30.56)

 

23(63.89)

 

29(80.56)

 

Metastasis

 

0.196

 

0.001*

 

0.265

 

0.818

Negative

29(42.03)

 

16(23.19)

 

32(46.38)

 

48(69.57)

 

Positive

3(75)

 

4(100)

 

3(75)

 

3(75)

 
  1. +High level expression of proteins
  2. *p value ≤0.05. The difference of protein expressions between clinicopathological parameters was statistically significant