Table 2 Ten GO processes and pathways most strongly enriched by meta-signature miRNA targets

0035556: intracellular signaling cascade

7.8E-13

3.3E-9

258

0007167: enzyme linked receptor protein signaling pathway

9.3E-10

2.0E-6

89

0006796: phosphate metabolic process

1.1E-8

1.1E-5

194

0007169: transmembrane receptor protein tyrosine kinase signaling pathway

9.6E-8

8.2E-5

61

0035556: protein kinase cascade

1.1E-7

7.8E-5

88

0006468: protein amino acid phosphorylation

2.2E-7

1.2E-4

138

0006355: regulation of transcription

2.4E-7

1.1E-4

435

0019220: regulation of phosphate metabolic process

2.5E-7

9.5E-5

107

0031328: positive regulation of cellular biosynthetic process

1.7E-6

3.7E-4

137

0043549: positive regulation of cell proliferation

2.6E-6

4.7E-4

91

KEGG Pathways

Pathway

p -Value

Benjamini

Genes

04722: Neurotrophin signaling pathway

5.0E-12

9.1E-10

49

04012: ErbB signaling pathway

8.2E-8

7.5E-6

33

05220: Chronic myeloid leukemia

9.5E-8

5.7E-6

30

05200: Pathways in cancer

1.7E-7

7.6E-6

81

04520: Adherens junction

1.9E-7

6.8E-6

30

04910: Insulin signaling pathway

1.6E-6

4.3E-5

41

05215: Prostate cancer

1.8E-6

4.1E-5

31

04722: p53 signaling pathway

8.0E-6

1.6E-4

25

04010: MAPK signaling pathway

1.2E-5

2.2E-4

64

05211: Renal cell carcinoma

1.4E-5

2.3E-4

25

Panther pathways

Pathway

p -Value

Benjamini

Genes

P00018: EGF receptor signaling pathway

6.3E-6

7.9E-4

43

P00047: PDGF signaling pathway

1.9E-4

8.1E-3

47

P04398: p53 pathway feedback loops 2

2.0E-4

6.4E-3

22

P00059: p53 pathway

3.5E-4

8.8E-3

34

P00021: FGF signaling pathway

6.8E-4

1.4E-2

36

P04393: Ras Pathway

3.5E-3

6.1E-2

25

P04397: p53 pathway by glucose deprivation

6.4E-3

9.6E-2

11

P00042: Muscarinic acetylcholine receptor 1 and 3 signaling pathway

8.3E-3

1.1E-1

18

P00039: Metabotropic glutamate receptor group III pathway

1.2E-2

1.4E-1

21

P00034: Integrin signalling pathway

1.6E-2

1.2E-1

47