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Table 1 Comparative analysis of IC50 (μM) values of various anticancer drugs in 2D and 3D cultures

From: Associations of chemo- and radio-resistant phenotypes with the gap junction, adhesion and extracellular matrix in a three-dimensional culture model of soft sarcoma

Cells

Doxorubicin

Gemcitabine

Docetaxel

2D

3D

2D

3D

2D

3D

HT1080

0.025 ± 0.002

4.27 ± 0.38*

4.26 ± 0.58

39.26 ± 2.76*

2.88 ± 0.54

69.81 ± 5.50*

RD

0.014 ± 0.01

2.74 ± 0.56*

1.89 ± 0.64

43.27 ± 3.32*

1.17 ± 0.16

55.87 ± 6.61*

SW872

0.066 ± 0.04

2.45 ± 0.72*

2.57 ± 0.15

18.34 ± 2.26*

1.85 ± 0.22

94.48 ± 10.25*

HOSS1

0.078 ± 0.011

4.61 ± 0.33*

6.23 ± 0.19

23.55 ± 3.65*

6.72 ± 0.87

103.2 ± 7.82*

  1. Each data point is represented as mean ± SD (n = 4-6)
  2. *P < 0.01 Vs repective 2D cultures