Skip to main content

Table 1 Comparative analysis of IC50 (μM) values of various anticancer drugs in 2D and 3D cultures

From: Associations of chemo- and radio-resistant phenotypes with the gap junction, adhesion and extracellular matrix in a three-dimensional culture model of soft sarcoma

Cells Doxorubicin Gemcitabine Docetaxel
2D 3D 2D 3D 2D 3D
HT1080 0.025 ± 0.002 4.27 ± 0.38* 4.26 ± 0.58 39.26 ± 2.76* 2.88 ± 0.54 69.81 ± 5.50*
RD 0.014 ± 0.01 2.74 ± 0.56* 1.89 ± 0.64 43.27 ± 3.32* 1.17 ± 0.16 55.87 ± 6.61*
SW872 0.066 ± 0.04 2.45 ± 0.72* 2.57 ± 0.15 18.34 ± 2.26* 1.85 ± 0.22 94.48 ± 10.25*
HOSS1 0.078 ± 0.011 4.61 ± 0.33* 6.23 ± 0.19 23.55 ± 3.65* 6.72 ± 0.87 103.2 ± 7.82*
  1. Each data point is represented as mean ± SD (n = 4-6)
  2. *P < 0.01 Vs repective 2D cultures