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Table 2 Univariate Cox proportional hazards model for overall survival (OS) and disease-free survival (DFS)

From: Developmental pluripotency-associated 4: a novel predictor for prognosis and a potential therapeutic target for colon cancer

 

DFS

OS

 

HR

95 % CI

P-value

HR

95 % CI

P-value

Age, years

      

<65

  

  

≥65

1.100

0.660–1.834

0.714

0.934

0.530–1.644

0.812

Gender

      

Male

      

Female

1.013

0.617–1.662

0.960

1.546

0.860–2.776

0.145

Tumor location

      

Right

  

  

Transverse

0.816

0.309–2.155

0.681

0.789

0.267–2.334

0.669

Left

1.392

0.619–3.130

0.423

1.291

0.512–3.252

0.589

Sigmoid colon

1.250

0.718–2.176

0.431

1.145

0.614–2.135

0.671

T stage

      

T1

0.494

0.119–2.049

0.331

0.988

0.299–3.259

0.984

T2

0.203

0.063–0.660

0.008*

0.394

0.138–1.130

0.083

T3

0.484

0.284–0.827

0.008*

0.520

0.280–0.966

0.039*

T4

  

  

N stage

      

N0

  

  

N1

5.887

3.025–11.456

<0.001*

4.157

2.009–8.602

<0.001*

N2

15.914

7.781–32.545

<0.001*

13.193

6.149–28.307

<0.001*

AJCC stage

      

I

  

  

II

1.108

0.305–4.027

0.877

0.667

0.201–2.215

0.508

III

6.823

2.097–22.199

0.001*

3.401

1.184–9.771

0.023*

IV

49.185

12.615–191.764

<0.001*

40.074

11.257–142.668

<0.001*

Differentiation

      

High

  

  

Moderate

1.315

0.750–2.306

0.340

1.458

0.764–2.780

0.253

Low

3.577

1.885–6.786

<0.001*

4.358

2.140–8.872

<0.001*

Vascular invasion

      

Yes

4.900

2.469–9.721

<0.001*

4.638

2.152–9.997

<0.001*

No

  

  

Ki-67 index

      

Negative

  

  

Weak

1.931

0.748–4.985

0.174

0.794

0.308–2.051

0.634

Positive

2.667

1.203–5.913

0.016*

1.175

0.592–2.335

0.645

DPPA4 expression

      

Negative

  

  

Weak

2.598

1.194–5.653

0.016*

2.117

0.862–5.196

0.102

Positive

6.118

3.004–12.462

<0.001*

6.348

2.875–14.014

<0.001*

  1. *P < 0.05 indicates a significant association among the variables