Fig. 1

The expression analysis of YY1 in normal skin tissues, benign nevi and melanoma tissues. (a) Relative YY1 mRNA expression levels in normal skin tissues, benign nevi and melanoma tissues; (b) The Statistical analysis of the association between YY1 level and metastasis state (primary and metastasis); (c) The Statistical analysis of the association between YY1 level and tumor stage (I, II, III and IV); (d) The relative level of YY1 mRNA in melanoma cell lines (WM852, WM1791C, WM8, WM209, FO-1, WM983A, WM793 and Daju) relative to 4 normal tissue controls; (e) Immunoblot of endogenous YAP1 protein level in 3 melanoma tissues, GC cell lines (WM852, WM1791C, WM8 and WM209) relative to 4 normal tissue controls; An unrelated protein GAPDH was used as the control. For the quantitative results, the data are presented as the mean ± SEM, and the error bars represent the standard deviation obtained from three independent experiments. *, p < 0.05; **, p < 0.01