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Table 1 Genes with potentially broad impact on the confrontation and the inhibitory capacity

From: Confrontation of fibroblasts with cancer cells in vitro: gene network analysis of transcriptome changes and differential capacity to inhibit tumor growth

Gene Method of prioritization Role Description
NFKBIA Confrontation DEG Co-regulated by RELA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha [Source: HGNC Symbol; Acc:7797]
IL1B Confrontation DEG Co-regulated by RELA interleukin 1, beta [Source: HGNC Symbol; Acc:5992]
RELT Confrontation DEG Co-regulated by RELA RELT tumor necrosis factor receptor [Source: HGNC Symbol; Acc:13764]
BHLHE40 Confrontation DEG Co-regulated by RELA basic helix-loop-helix family, member e40 [Source: HGNC Symbol; Acc:1046]
FOS Connected to confrontation DEGs Transcription factor FBJ murine osteosarcoma viral oncogene homolog [Source: HGNC Symbol; Acc:3796]
SRF Connected to confrontation DEGs Transcription factor serum response factor (c-fos serum response element-binding transcription factor) [Source: HGNC Symbol; Acc:11291]
FOSB Confrontation DEG Co-regulated by RELA FBJ murine osteosarcoma viral oncogene homolog B [Source: HGNC Symbol; Acc:3797]
CYR61 Connected to confrontation DEGs Pro-inflammatory signature (Erez et al., 2012) cysteine-rich, angiogenic inducer, 61 [Source: HGNC Symbol; Acc:2654]
IKBKB Connected to confrontation DEGs Pro-inflammatory signature (Erez et al., 2012) inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta [Source: HGNC Symbol; Acc:5960]
IKBKE Connected to confrontation DEGs Pro-inflammatory signature (Erez et al., 2012) inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon [Source: HGNC Symbol; Acc:14552]
IKBKG Connected to confrontation DEGs Pro-inflammatory signature (Erez et al., 2012) inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma [Source: HGNC Symbol; Acc:5961]
IKBKG Connected to confrontation DEGs Pro-inflammatory signature (Erez et al., 2012) Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma, isoform CRA_b [Source: UniProtKB/TrEMBL; Acc:D3DWY0]
NR4A2 Connected to confrontation DEGs Pro-inflammatory signature (Erez et al., 2012) nuclear receptor subfamily 4, group A, member 2 [Source: HGNC Symbol; Acc:7981]
PDGFRA Connected to confrontation DEGs Pro-inflammatory signature (Erez et al., 2012) platelet-derived growth factor receptor, alpha polypeptide [Source: HGNC Symbol; Acc:8803]
ANXA4 inhibition DEG Co-regulated by FOXA1 annexin A4 [Source: HGNC Symbol; Acc:542]
CDK6 inhibition DEG Co-regulated by FOXA1 cyclin-dependent kinase 6 [Source: HGNC Symbol; Acc:1777]
KAZN inhibition DEG Co-regulated by FOXA1 kazrin, periplakin interacting protein [Source: HGNC Symbol; Acc:29173]
RMND5A inhibition DEG Co-regulated by FOXA1 required for meiotic nuclear division 5 homolog A (S. cerevisiae) [Source: HGNC Symbol; Acc:25850]
TNS3 inhibition DEG Co-regulated by FOXA1 tensin 3 [Source: HGNC Symbol; Acc:21616]
IL6 Connected to inhibition DEGs Potential regulator interleukin 6 (interferon, beta 2) [Source: HGNC Symbol; Acc:6018]
MAPK8 Connected to inhibition DEGs Potential regulator mitogen-activated protein kinase 8 [Source: HGNC Symbol; Acc:6881]
MAP2K4 Connected to inhibition DEGs Potential regulator mitogen-activated protein kinase kinase 4 [Source: HGNC Symbol; Acc:6844]
PRKCA Connected to inhibition DEGs Potential regulator protein kinase C, alpha [Source: HGNC Symbol; Acc:9393]
YBX1 Connected to inhibition DEGs Transcription factor Y box binding protein 1 [Source: HGNC Symbol; Acc:8014]
GFI1 Connected to inhibition DEGs Transcription factor growth factor independent 1 transcription repressor [Source: HGNC Symbol; Acc:4237]
ESR1 Connected to inhibition DEGs Transcription factor estrogen receptor 1 [Source: HGNC Symbol; Acc:3467]
ETS1 Connected to inhibition DEGs Transcription factor v-ets avian erythroblastosis virus E26 oncogene homolog 1 [Source: HGNC Symbol; Acc:3488]
ETS2 Connected to inhibition DEGs Transcription factor v-ets avian erythroblastosis virus E26 oncogene homolog 2 [Source: HGNC Symbol; Acc:3489]
AR Connected to inhibition DEGs Transcription factor androgen receptor [Source: HGNC Symbol; Acc:644]
GATA1 Connected to inhibition DEGs Transcription fact or GATA binding protein 1 (globin transcription factor 1) [Source: HGNC Symbol; Acc:4170]
GATA2 Connected to inhibition DEGs Transcription factor GATA binding protein 2 [Source: HGNC Symbol; Acc:4171]
GATA3 Connected to inhibition DEGs Transcription factor GATA binding protein 3 [Source: HGNC Symbol; Acc:4172]
PAX2 Connected to inhibition DEGs Transcription factor paired box 2 [Source: HGNC Symbol; Acc:8616]
JUN Connected to inhibition DEGs Transcription factor jun proto-oncogene [Source: HGNC Symbol; Acc:6204]
STAT3 Connected to inhibition DEGs Transcription factor signal transducer and activator of transcription 3 (acute-phase response factor) [Source: HGNC Symbol; Acc:11364]
STAT5A Connected to inhibition DEGs Transcription factor signal transducer and activator of transcription 5A [Source: HGNC Symbol; Acc:11366]
CAMK2A Confrontation DEG Involved in TGFbeta signaling, associated with survival calcium/calmodulin-dependent protein kinase II alpha [Source: HGNC Symbol; Acc:1460]
CDK6 Confrontation DEG Involved in TGFbeta signaling, associated with survival cyclin-dependent kinase 6 [Source: HGNC Symbol; Acc:1777]
CDKN2B Confrontation DEG Involved in TGFbeta signaling, associated with survival cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) [Source: HGNC Symbol; Acc:1788]
NR4A1 Confrontation DEG Involved in TGFbeta signiling, associated with survival nuclear receptor subfamily 4, group A, member 1 [Source: HGNC Symbol; Acc:7980]
SMAD3 Confrontation DEG Involved in TGFbeta signiling, associated with survival SMAD family member 3 [Source: HGNC Symbol; Acc:6769]
TGFB1 Confrontation DEG Involved in TGFbeta signiling, associated with survival transforming growth factor, beta 1 [Source: HGNC Symbol; Acc:11766]
TGFB3 Confrontation DEG Involved in TGFbeta signiling, associated with survival transforming growth factor, beta 3 [Source: HGNC Symbol; Acc:11769]
EFNB2 inhibition DEG Associated with survival ephrin-B2 [Source: HGNC Symbol; Acc:3227]
TMEM220 inhibition DEG Associated with survival transmembrane protein 220 [Source: HGNC Symbol; Acc:33757]
TFAP2C inhibition DEG Associated with survival transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) [Source: HGNC Symbol; Acc:11744]
RPSAP52 inhibition DEG Associated with survival ribosomal protein SA pseudogene 52 [Source: HGNC Symbol; Acc:35752]
SLC40A1 inhibition DEG Associated with survival solute carrier family 40 (iron-regulated transporter), member 1 [Source: HGNC Symbol; Acc:10909]
CYP1B1 inhibition DEG Associated with survival cytochrome P450, family 1, subfamily B, polypeptide 1 [Source: HGNC Symbol; Acc:2597]
CHAC1 inhibition DEG Associated with survival ChaC, cation transport regulator homolog 1 (E. coli) [Source: HGNC Symbol; Acc:28680]
CCL2 inhibition DEG Associated with survival chemokine (C-C motif) ligand 2 [Source: HGNC Symbol; Acc:10618]
PSAT1 inhibition DEG Associated with survival phosphoserine aminotransferase 1 [Source: HGNC Symbol; Acc:19129]
RCAN2 inhibition DEG Associated with survival regulator of calcineurin 2 [Source: HGNC Symbol; Acc:3041]
SCG2 inhibition DEG Associated with survival secretogranin II [Source: HGNC Symbol; Acc:10575]
AEBP1 inhibition DEG Associated with survival AE binding protein 1 [Source: HGNC Symbol; Acc:303]
MXRA8 inhibition DEG Associated with survival matrix-remodelling associated 8 [Source: HGNC Symbol; Acc:7542]
TBC1D1 inhibition DEG Associated with survival TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1 [Source: HGNC Symbol; Acc:11578]
ITGA6 inhibition DEG Associated with survival integrin, alpha 6 [Source: HGNC Symbol; Acc:6142]
PLAUR inhibition DEG Associated with survival plasminogen activator, urokinase receptor [Source: HGNC Symbol; Acc:9053]