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Table 1 Cohort characteristics, N = 106

From: Piwi-interacting RNAs as novel prognostic markers in clear cell renal cell carcinomas

Characteristics

Primary ccRCC, non-metastatica N = 76

Primary ccRCC, metastatica N = 30

P valueb

Age, median years (range)

65 (37–87)

61 (43–76)

0.153

Sex, n (%)

 Male

58 (76)

21 (70)

0.621

 Female

18 (24)

9 (30)

 

Pathological stage, n (%)

 pT1

48 (63)

5 (17)

<0.0001

 pT2

2 (3)

1 (3)

 

 pT3

25 (33)

21 (70)

 

 pT4

1 (1)

3 (10)

 

Fuhrman grade, n (%)

 G1

11 (14)

0 (0)

<0.0001

 G2

60 (79)

11 (37)

 

 G3

3 (4)

16 (53)

 

 G4

2 (3)

3 (10)

 

Surgical margins, n (%)

 R0

71 (93)

21 (70)

0.003

 R1/2

5 (7)

9 (30)

 

Tumor size, median mm (range)

48 (20–180)

85 (35–170)

<0.0001

Patients followed,c n (%)

76 (100)

30 (100)

<0.0001

 Metastasis at follow-up

17 (29)

  

 Death at follow-up

12 (16)

25 (83)

 

Follow-up, median month (range)

 Overall

65.7 (1.0–121)

9.5 (1.2–65.2)

<0.0001

 No recurrence

69.9 (5.3–121)

  

 Recurrence

30.4 (1.0–116)

  
  1. Abbreviations: ccRCC clear cell renal cell carcinoma, G histopathological grading according to Fuhrman, pT pathological tumor classification, R surgical margin classification
  2. aImaging techniques was used to provide evidence of presence/non-presence of metastases before surgery
  3. b p value from Fisher’s exact test or Chi-square test for trend and Mann–Whitney U-test
  4. cIn four cases, only the survival but not the recurrence situation could be assessed