Fig. 6

Antiangiogenic effects of HF in the in vivo model of APL. a Immunohistochemistry staining for VEGF in BM samples of leukemic and leukemic mice treated for 21 days with HF (Leuk-HF). b Percentage of VEGF positive cells detected by VEGF-staining by immunohistochemistry and analysis of three microscopic fields (400×). c mRNA expression in BM samples of leukemic and Leuk-HF mice. Doted line indicates non-leukemic mice (Fold change = 1). *P < 0.05, **P < 0.001 (one-way ANOVA). Data summarize one representative experiment (n = 5) (error bars, sd)