Hypoxia-inducible MiR-182 promotes angiogenesis by targeting RASA1 in hepatocellular carcinoma

Table 2 The relationship between miR-182 expression and clinicopathological characteristics in human HCC patients

Variables	All patients	miR-182 expression		P value
Variables	(n = 36)	low^a	high^a	P value
Age (years)
≤55	12	7	5	0.725
>55	24	11	13
Gender
Male	28	13	15	0.691
Female	8	5	3
Size of tumor (cm)
≤5	16	12	4	0.018*
>5	20	6	14
Number of tumor
Single	20	12	9	0.5
Multiple	16	6	9
Portal vein invasion
Negative	25	16	9	0.027*
Positive	11	2	9
TNM staging
I, II	21	13	8	0.176
III	15	5	10
Grade
Well + Moderate	27	15	12	0.09
Poor	9	3	6
AFP (ng/ml)
≤400	10	6	4	0.711
>400	26	12	14

For analysis of correlation between miR-182 expression and clinical features, fisher exact tests were used. Results were considered statistically significant at P <0 .05 *
^aThe median expression level was used as the cut-off. Low expression of miR-182 in 18 patients was classified as values below the 50th percentile. High miR-182 expression in 18 patients was classified as values above the 50th percentile

ISSN: 1756-9966