|
Macroscopy & microscopy
|
Control (n = 8)
|
MNU (n = 8)
|
MNU + Met (n = 8)
|
P value
|
|---|
|
Frequency of tumoringenivity [%(n/n)]
|
0
|
100(8/8)
|
87.5(7/8)
|
0.5
|
|
Areas of tumors [mm2(n)]
|
0
|
48.84 ± 17.82(in 8)
|
17.5 ± 10.88(in 7)
|
0.0014
|
|
Preneoplasic lesions[%(n/n)]
| | | | |
|
Hyperplasia
|
0
|
0
|
0
|
1
|
|
Dysplasia
|
0
|
0
|
12.5(1/8)
|
0.302
|
|
Neoplasic lesions[%n/n]
| | | | |
|
Papillary tumor
|
0
|
37.5(3/8)
|
75(6/8)
|
0.046
|
|
Carcinoma in situ
|
0
|
75(6/8)
|
37.5(3/8)
|
0.046
|
|
Infiltrative tumor
|
0
|
50(4/8)
|
0
|
0.021
|
|
Accompanied other pathology [%(n/n)]
| | | | |
|
Squamous differentiation
|
0
|
37.5(3/8)
|
12.5(1/8)
|
0.248
|
|
Sarcoma
|
0
|
12.5(1/8)
|
0
|
0.302
|
-
P values represent comparion between MNU group and Met group
- Note: Multiple lesions at various stages were detected in the same bladders of MNU-induced rats, including papillary tumors, CIS, infiltrative tumors and sarcomas. Upon treatment with metformin, MNU-induced rats were only detected with dysplasia, papillary tumors and CIS. Tumor incidence and tumor size (areas) in MNU-induced rats were reduced upon treatment with metformin
