Heterozygote of TAP1 Codon637 decreases susceptibility to HPV infection but increases susceptibility to esophageal cancer among the Kazakh populations

Table 5 Correlations of clinicopathological parameters and TAP1 D637G polymorphism in Kazakh patients with ESCC

Parameters	AA	AG/GG	OR (95 % CI)
Parameters	(Cases/controls)	(Cases/controls)	OR (95 % CI)
Gender^a
Male	48/92	46/62	1.422 (0.848–2.385)
Female	25/81	31/48	2.093 (1.107–3.954)*
Age^a
≤52	30/91	30/60	1.517 (0.831–2.769)
>52	43/82	37/50	1.411 (0804–2.478)
Tumor depth^b
T1/T2	37/173	48/110	2.040 (1.249–3.333)**
T3/T4	36/173	29/110	1.267 (0.735–2.184)
Histologic grade (G)^b
G1	27/173	27/110	1.573 (0.877–2.822)
G2	38/173	40/110	1.656 (0.999–2.741)
G3	8/173	10/110	1.966 (0.753–5134)
Clinical stage^b
I/II	53/173	58/110	1.721 (1.106–2.679)*
III/IV	20/173	19/110	1.494 (0.763–2.925)

We consider the common homozygotes of TAP1 as ORs of 1.000 for the reference genotype
“*”represents P < 0.05, “**”indicates P < 0.01, “***”depicts P < 0.001
^aStratification analysis to evaluate the effects of variant genotypes on the risk of ESCC by age and sex
^bLogistic regression analysis for the effects of TAP1 variants on risk of ESCC with different tumor depth, histologic grade and clinical stage through logistic regression analyses. G1: well differentiated; G2: moderately differentiated; G3: poorly differentiated

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