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Table 5 Correlations of clinicopathological parameters and TAP1 D637G polymorphism in Kazakh patients with ESCC

From: Heterozygote of TAP1 Codon637 decreases susceptibility to HPV infection but increases susceptibility to esophageal cancer among the Kazakh populations

Parameters AA AG/GG OR (95 % CI)
(Cases/controls) (Cases/controls)
Gendera    
Male 48/92 46/62 1.422 (0.848–2.385)
Female 25/81 31/48 2.093 (1.107–3.954)*
Agea    
≤52 30/91 30/60 1.517 (0.831–2.769)
>52 43/82 37/50 1.411 (0804–2.478)
Tumor depthb    
T1/T2 37/173 48/110 2.040 (1.249–3.333)**
T3/T4 36/173 29/110 1.267 (0.735–2.184)
Histologic grade (G)b    
G1 27/173 27/110 1.573 (0.877–2.822)
G2 38/173 40/110 1.656 (0.999–2.741)
G3 8/173 10/110 1.966 (0.753–5134)
Clinical stageb    
I/II 53/173 58/110 1.721 (1.106–2.679)*
III/IV 20/173 19/110 1.494 (0.763–2.925)
  1. We consider the common homozygotes of TAP1 as ORs of 1.000 for the reference genotype
  2. “*”represents P < 0.05, “**”indicates P < 0.01, “***”depicts P < 0.001
  3. aStratification analysis to evaluate the effects of variant genotypes on the risk of ESCC by age and sex
  4. bLogistic regression analysis for the effects of TAP1 variants on risk of ESCC with different tumor depth, histologic grade and clinical stage through logistic regression analyses. G1: well differentiated; G2: moderately differentiated; G3: poorly differentiated