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Fig. 4 | Journal of Experimental & Clinical Cancer Research

Fig. 4

From: Cell death induction by the BH3 mimetic GX15-070 in thyroid carcinoma cells

Fig. 4

Increased activity of caspase 3 and 7 (a), increase in the concentration of cleaved caspase 3 fragments as a sign of progressing caspase activity (b) and increased LDH-release into the cell culture medium (c) after treatment with 0.1 μM GX15-070 for 2, 6, 16 and 24 h in different thyroid carcinoma cell lines. Values were determined by Apo-One assay, an ELISA specific for caspase 3 fragments and CytoTox-assay and are depicted as percent of vehicle-treated control. Data represent mean values of eight-fold determinations ± standard deviation; * indicates significant increase (p < 0.05, Student’s t-test)

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