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Table 2 Distribution of cell cycle phases in vehicle-treated thyroid carcinoma cells and cells treated for 24 h with 0.1 μM GX15-070

From: Cell death induction by the BH3 mimetic GX15-070 in thyroid carcinoma cells

Cell line

Stimulation

% subG1

% G1

% G2/M

% S

FTC236 (FTC)

unstimulated

0.3 ± 0.04

36.7 ± 2.4

17.0 ± 1.1

46.3 ± 3.1

24 h GX15-070

9.9 ± 2.4 *

81.9 ± 5.3 *

12.2 ± 1.7 *

6.0 ± 0.9 *

ML1 (FTC)

unstimulated

1.2 ± 0.3

39.4 ± 1.7

28.5 ± 1.5

32.1 ± 1.8

24 h GX15-070

34.8 ± 3.5 *

82.2 ± 5.4 *

14.3 ± 0.9 *

3.5 ± 0.4 *

BHT101 (PTC)

unstimulated

3.7 ± 0.6

52.5 ± 3.9

16.3 ± 1.1

31.3 ± 2.2

24 h GX15-070

27.9 ± 3.0 *

76.1 ± 5.4 *

15.4 ± 1.4

8.6 ± 1.0 *

SW1736 (ATC)

unstimulated

2.4 ± 0.2

35.9 ± 1.7

24.3 ± 2.0

39.8 ± 2.5

24 h GX15-070

9.3 ± 1.3 *

77.5 ± 5.5 *

11.8 ± 0.9 *

10.8 ± 1.1 *

C643 (ATC)

unstimulated

0.7 ± 0.1

54.5 ± 4.2

13.9 ± 0.9

38.6 ± 2.7

24 h GX15-070

21.7 ± 2.7 *

75.6 ± 5.8 *

10.4 ± 1.2 *

14.0 ± 0.9 *

HTh7 (ATC)

unstimulated

1.1±0.2

55.5 ± 3.9

11.3 ± 0.9

33.2 ± 1.8

24 h GX15-070

4.1 ± 0.3 *

80.0 ± 5.7 *

3.9 ± 0.2 *

16.1 ± 1.0 *

  1. Values for G1-, G2/M-, and S-phases are determined for the living cells that were not included in the sub-G1-peak. * indicates significant changes (p < 0.05, Student’s t-test)