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Table 2 Distribution of cell cycle phases in vehicle-treated thyroid carcinoma cells and cells treated for 24 h with 0.1 μM GX15-070

From: Cell death induction by the BH3 mimetic GX15-070 in thyroid carcinoma cells

Cell line Stimulation % subG1 % G1 % G2/M % S
FTC236 (FTC) unstimulated 0.3 ± 0.04 36.7 ± 2.4 17.0 ± 1.1 46.3 ± 3.1
24 h GX15-070 9.9 ± 2.4 * 81.9 ± 5.3 * 12.2 ± 1.7 * 6.0 ± 0.9 *
ML1 (FTC) unstimulated 1.2 ± 0.3 39.4 ± 1.7 28.5 ± 1.5 32.1 ± 1.8
24 h GX15-070 34.8 ± 3.5 * 82.2 ± 5.4 * 14.3 ± 0.9 * 3.5 ± 0.4 *
BHT101 (PTC) unstimulated 3.7 ± 0.6 52.5 ± 3.9 16.3 ± 1.1 31.3 ± 2.2
24 h GX15-070 27.9 ± 3.0 * 76.1 ± 5.4 * 15.4 ± 1.4 8.6 ± 1.0 *
SW1736 (ATC) unstimulated 2.4 ± 0.2 35.9 ± 1.7 24.3 ± 2.0 39.8 ± 2.5
24 h GX15-070 9.3 ± 1.3 * 77.5 ± 5.5 * 11.8 ± 0.9 * 10.8 ± 1.1 *
C643 (ATC) unstimulated 0.7 ± 0.1 54.5 ± 4.2 13.9 ± 0.9 38.6 ± 2.7
24 h GX15-070 21.7 ± 2.7 * 75.6 ± 5.8 * 10.4 ± 1.2 * 14.0 ± 0.9 *
HTh7 (ATC) unstimulated 1.1±0.2 55.5 ± 3.9 11.3 ± 0.9 33.2 ± 1.8
24 h GX15-070 4.1 ± 0.3 * 80.0 ± 5.7 * 3.9 ± 0.2 * 16.1 ± 1.0 *
  1. Values for G1-, G2/M-, and S-phases are determined for the living cells that were not included in the sub-G1-peak. * indicates significant changes (p < 0.05, Student’s t-test)