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Table 2 Mean ± SD of body weight, colon surface area (length × width in cm), count of colonic tumours by gross and dissecting microscope, large ACF, number of tumour/colon surface area ratio (NT/CS), serum 25-OH vitamin D concentrations, liver enzymes and renal function parameters and in the different study groups

From: Vitamin D3 enhances the tumouricidal effects of 5-Fluorouracil through multipathway mechanisms in azoxymethane rat model of colon cancer

  Normal group AOM group 5-FU group VitD group 5-FU/D group
Body weight (g) 231.57 ± 20.01 221.97 ± 23.01 238.42 ± 13.64 230.1 ± 22.2 229.5 ± 18.7
Colon surface area (cm2) 19.1 ± 2.2 18.89 ± 3.43 19.81 ± 1.84 21.5 ± 2.29 20.4 ± 4.1
Tumour count Gross N/A 12.5 ± 3.21 8.7 ± 2.9** 8.1 ± 2.5** 6.2 ± 1.6**,***
Dissecting Microscope N/A 17.36 ± 4.6 8.8 ± 1.75** 10.04 ± 3.6** 5.78 ± 1.1**,***,****
Total N/A 29.16 ± 2.92 16.66 ± 4.41** 19.33 ± 1.8** 11.5 ± 1.65**,***,****
large ACF (with ≥ 4 crypts/focus) 0 41.3 ± 8.0 21.3 ± 5.3** 19.7 ± 7.6** 11.2 ± 4.2**,***,****
NT/CS Ratio N/A 1.5 ± 0.14 0.83 ± 0.14** 0.86 ± 0.06** 0.6 ± 0.18**,***,****
25-OH Vitamin D (ng/mL) 46.19 ± 8.1 36.6 ± 6.7* 35.7 ± 9.5* 68.5 ± 9.1*,**,*** 65.8 ± 9.1*,**,***
ALP (IU/L) 122.6 ± 11.2 125.7 ± 9.7 120.8 ± 12.4 127.3 ± 11.9 121.6 ± 11.1
ALT (U/L) 67 ± 2.4 71.2 ± 6.7 68.7 ± 4.1 66.4 ± 5.3 67.3 ± 3.7
AST (U/L) 92.4 ± 24.2 105.8 ± 26.7 109 ± 21.6 103 ± 19.8 99 ± 11.9
Creatinine (mg/dL) 0.22 ± 0.03 0.2 ± 0.06 0.2 ± 0.03 0.19 ± 0.03 0.21 ± 0.05
Urea (mg/dL) 47.6 ± 5.1 52.3 ± 4 51.6 ± 9.5 47.3 ± 5.8 49.1 ± 3.7
BUN (mg/dL) 22.2 ± 2.4 24.4 ± 1.9 26.3 ± 4.4 22 ± 2.7 21.4 ± 2.1
  1. *P < 0.05 compared with normal; **P < 0.05 compared with AOM group, ***P < 0.05 compared with 5-FU group and ****P < 0.05 compared with VitD group