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Table 3 Mean ± SD of immunohistochemistry scores for TGF-β1, TGF-β receptor II, Smad 4, β-catenin, iNOS and HSP-90 proteins in colon specimens

From: Vitamin D3 enhances the tumouricidal effects of 5-Fluorouracil through multipathway mechanisms in azoxymethane rat model of colon cancer

  Normal group AOM group 5-FU group VitD group 5-FU/D group
TGF-β1 315.5 ± 31.2 136.4 ± 23.4* 301.48 ± 44.3** 323.9 ± 38.5** 348.1 ± 27.8*,**,***
TGF-β receptor II 333.7 ± 28.7 121.4 ± 19.2* 135.7 ± 17.6* 229.2 ± 26.8*,**,*** 377.2 ± 17.8*,**,***,****
Smad 4 301.1 ± 26 147.2 ± 20.3* 216.1 ± 23.9*,** 258.7 ± 31.6*,**,*** 386.3 ± 12.2*,**,***,****
β-catenin 61 ± 16.7 370.6 ± 28.7* 267.6 ± 35.3*,** 259.6 ± 30.1*,** 149.7 ± 22.6*,**,***,****
iNOS 39.4 ± 9.5 373.1 ± 26.8* 261.8 ± 47.2*,** 188.1 ± 33.6*,**,*** 113.1 ± 21.6*,**,***,****
HSP-90 112.7 ± 27.6 376.5 ± 22.6* 302.4 ± 36.8*,** 174.7 ± 28.6*,**,*** 88 ± 15.4*,**,***,****
  1. *P < 0.05 compared with normal; **P < 0.05 compared with AOM group, ***P < 0.05 compared with 5-FU group and ****P < 0.05 compared with VitD group