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Table 3 Mean ± SD of immunohistochemistry scores for TGF-β1, TGF-β receptor II, Smad 4, β-catenin, iNOS and HSP-90 proteins in colon specimens

From: Vitamin D3 enhances the tumouricidal effects of 5-Fluorouracil through multipathway mechanisms in azoxymethane rat model of colon cancer

 

Normal group

AOM group

5-FU group

VitD group

5-FU/D group

TGF-β1

315.5 ± 31.2

136.4 ± 23.4*

301.48 ± 44.3**

323.9 ± 38.5**

348.1 ± 27.8*,**,***

TGF-β receptor II

333.7 ± 28.7

121.4 ± 19.2*

135.7 ± 17.6*

229.2 ± 26.8*,**,***

377.2 ± 17.8*,**,***,****

Smad 4

301.1 ± 26

147.2 ± 20.3*

216.1 ± 23.9*,**

258.7 ± 31.6*,**,***

386.3 ± 12.2*,**,***,****

β-catenin

61 ± 16.7

370.6 ± 28.7*

267.6 ± 35.3*,**

259.6 ± 30.1*,**

149.7 ± 22.6*,**,***,****

iNOS

39.4 ± 9.5

373.1 ± 26.8*

261.8 ± 47.2*,**

188.1 ± 33.6*,**,***

113.1 ± 21.6*,**,***,****

HSP-90

112.7 ± 27.6

376.5 ± 22.6*

302.4 ± 36.8*,**

174.7 ± 28.6*,**,***

88 ± 15.4*,**,***,****

  1. *P < 0.05 compared with normal; **P < 0.05 compared with AOM group, ***P < 0.05 compared with 5-FU group and ****P < 0.05 compared with VitD group