| Whole population | Arm A (n = 32) | Arm B (n = 31) | Arm C (n = 31) | ||||
---|---|---|---|---|---|---|---|---|
Toxicity (%) | All grade | Grade 3/4 | All grade | Grade 3/4 | All grade | Grade 3/4 | All grade | Grade 3/4 |
Hematologic | Â | Â | Â | Â | Â | Â | Â | Â |
 Neutropenia | 86 (91.5) | 79 (84.0) | 29 (90.6) | 26 (81.3) | 30 (96.8) | 27 (87.0) | 27 (87.1) | 26 (83.9) |
 Leukopenia | 86 (91.5) | 61 (64.9) | 28 (87.5) | 20 (62.5) | 30 (96.8) | 23 (74.2) | 28 (90.3) | 18 (58.1) |
 Thrombocytopenia | 17 (18.1) | 1 (1.1) | 6 (18.8) | 0 | 5 (16.1) | 1 (3.2) | 6 (19.4) | 0 |
 Anemia | 56 (59.6) | 5 (5.3) | 15 (46.9) | 0 | 20 (64.5) | 3 (9.7) | 21 (67.7) | 2 (6.5) |
 Febrile neutropenia | 18 (19.1) | 18 (19.1) | 6 (18.8) | 6 (18.8) | 5 (16.1) | 5 (16.1) | 7 (22.6) | 7 (22.6) |
Non-hematologic | Â | Â | Â | Â | Â | Â | Â | Â |
 Hypersensitivity | 3 (3.2) | 3 (3.2) | 2 (6.3) | 2 (6.3) | 0 | 0 | 1 (3.2) | 1 (3.2) |
 Rash | 3 (3.2) | 0 | 0 | 0 | 1 (3.2) | 0 | 2 (3.3) | 0 |
 Peripheral neuropathy | 40 (42.6) | 2 (2.1) | 13 (40.6) | 0 | 13 (41.9) | 1 (3.2) | 14 (45.2) | 1 (3.2) |
 Alopecia | 37 (39.4) | 0 | 12 (37.5) | 0 | 12 (38.7) | 0 | 13 (41.9) | 0 |
 Fatigue | 47 (50.0) | 0 | 17 (53.1) | 0 | 16 (51.6) | 0 | 14 (45.2) | 0 |
 Nausea | 49 (52.1) | 3 (3.2) | 15 (46.9) | 0 | 18 (58.0) | 0 | 16 (51.6) | 3 (9.7) |
 Vomiting | 44 (46.8) | 3 (3.2) | 16 (50.0) | 0 | 12 (38.7) | 0 | 16 (51.6) | 3 (9.7) |
 Diarrhea | 28 (29.8) | 2 (2.1) | 8 (25.0) | 0 | 8 (25.8) | 2 (6.5) | 12 (38.7) | 0 |
 Constipation | 14 (14.9) | 0 | 5 (15.6) | 0 | 6 (19.4) | 0 | 3 (9.7) | 0 |
 Liver dysfunction | 5 (5.3) | 0 | 1 (3.1) | 0 | 3 (9.7) | 0 | 1 (3.2) | 0 |
 Renal dysfunction | 1 (1.1) | 0 | 0 | 0 | 1 (3.2) | 0 | 0 | 0 |
 Mucositis | 3 (3.2) | 0 | 1 (3.1) | 0 | 1 (3.2) | 0 | 1 (3.2) | 0 |
 Abdominal pain | 14 (14.9) | 0 | 3 (9.4) | 0 | 3 (9.7) | 0 | 8 (25.8) | 0 |
 Stomach discomfort | 2 (2.1) | 0 | 0 | 0 | 2 (6.5) | 0 | 0 | 0 |
 Abdominal discomfort | 2 (2.1) | 1 (1.1) | 1 (3.1) | 1 (3.1) | 1 (3.2) | 0 | 0 | 0 |
 Loss of appetite | 46 (48.9) | 2 (2.1) | 14 (43.8) | 1 (3.1) | 17 (54.8) | 0 | 15 (48.4) | 1 (3.2) |
 Hyperpigmentation | 2 (2.1) | 0 | 0 | 0 | 2 (6.5) | 0 | 0 | 0 |
 Edema | 6 (6.4) | 1 (1.1) | 3 (9.4) | 1 (3.1) | 2 (6.5) | 0 | 1 (3.2) | 0 |
 Dizziness | 12 (12.8) | 0 | 4 (12.5) | 0 | 4 (12.9) | 0 | 4 (12.9) | 1 (3.2) |
 Myalgia and Arthralgia | 7 (7.4) | 0 | 1 (3.1) | 0 | 2 (6.5) | 0 | 4 (12.9) | 0 |
 Insomia | 4 (4.3) | 0 | 3 (9.4) | 0 | 0 | 0 | 1 (3.2) | 0 |
 Dyspnea | 4 (4.3) | 0 | 2 (6.3) | 0 | 2 (6.5) | 0 | 0 | 0 |
 Delacrimation | 1 (1.1) | 0 | 0 | 0 | 0 | 0 | 1 (3.2) | 0 |
 Blurred vision | 1 (1.1) | 0 | 0 | 0 | 1 (3.2) | 0 | 0 | 0 |