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Table 3 Toxicities (n = 94)

From: Intermittent high dose proton pump inhibitor enhances the antitumor effects of chemotherapy in metastatic breast cancer

 

Whole population

Arm A (n = 32)

Arm B (n = 31)

Arm C (n = 31)

Toxicity (%)

All grade

Grade 3/4

All grade

Grade 3/4

All grade

Grade 3/4

All grade

Grade 3/4

Hematologic

        

 Neutropenia

86 (91.5)

79 (84.0)

29 (90.6)

26 (81.3)

30 (96.8)

27 (87.0)

27 (87.1)

26 (83.9)

 Leukopenia

86 (91.5)

61 (64.9)

28 (87.5)

20 (62.5)

30 (96.8)

23 (74.2)

28 (90.3)

18 (58.1)

 Thrombocytopenia

17 (18.1)

1 (1.1)

6 (18.8)

0

5 (16.1)

1 (3.2)

6 (19.4)

0

 Anemia

56 (59.6)

5 (5.3)

15 (46.9)

0

20 (64.5)

3 (9.7)

21 (67.7)

2 (6.5)

 Febrile neutropenia

18 (19.1)

18 (19.1)

6 (18.8)

6 (18.8)

5 (16.1)

5 (16.1)

7 (22.6)

7 (22.6)

Non-hematologic

        

 Hypersensitivity

3 (3.2)

3 (3.2)

2 (6.3)

2 (6.3)

0

0

1 (3.2)

1 (3.2)

 Rash

3 (3.2)

0

0

0

1 (3.2)

0

2 (3.3)

0

 Peripheral neuropathy

40 (42.6)

2 (2.1)

13 (40.6)

0

13 (41.9)

1 (3.2)

14 (45.2)

1 (3.2)

 Alopecia

37 (39.4)

0

12 (37.5)

0

12 (38.7)

0

13 (41.9)

0

 Fatigue

47 (50.0)

0

17 (53.1)

0

16 (51.6)

0

14 (45.2)

0

 Nausea

49 (52.1)

3 (3.2)

15 (46.9)

0

18 (58.0)

0

16 (51.6)

3 (9.7)

 Vomiting

44 (46.8)

3 (3.2)

16 (50.0)

0

12 (38.7)

0

16 (51.6)

3 (9.7)

 Diarrhea

28 (29.8)

2 (2.1)

8 (25.0)

0

8 (25.8)

2 (6.5)

12 (38.7)

0

 Constipation

14 (14.9)

0

5 (15.6)

0

6 (19.4)

0

3 (9.7)

0

 Liver dysfunction

5 (5.3)

0

1 (3.1)

0

3 (9.7)

0

1 (3.2)

0

 Renal dysfunction

1 (1.1)

0

0

0

1 (3.2)

0

0

0

 Mucositis

3 (3.2)

0

1 (3.1)

0

1 (3.2)

0

1 (3.2)

0

 Abdominal pain

14 (14.9)

0

3 (9.4)

0

3 (9.7)

0

8 (25.8)

0

 Stomach discomfort

2 (2.1)

0

0

0

2 (6.5)

0

0

0

 Abdominal discomfort

2 (2.1)

1 (1.1)

1 (3.1)

1 (3.1)

1 (3.2)

0

0

0

 Loss of appetite

46 (48.9)

2 (2.1)

14 (43.8)

1 (3.1)

17 (54.8)

0

15 (48.4)

1 (3.2)

 Hyperpigmentation

2 (2.1)

0

0

0

2 (6.5)

0

0

0

 Edema

6 (6.4)

1 (1.1)

3 (9.4)

1 (3.1)

2 (6.5)

0

1 (3.2)

0

 Dizziness

12 (12.8)

0

4 (12.5)

0

4 (12.9)

0

4 (12.9)

1 (3.2)

 Myalgia and Arthralgia

7 (7.4)

0

1 (3.1)

0

2 (6.5)

0

4 (12.9)

0

 Insomia

4 (4.3)

0

3 (9.4)

0

0

0

1 (3.2)

0

 Dyspnea

4 (4.3)

0

2 (6.3)

0

2 (6.5)

0

0

0

 Delacrimation

1 (1.1)

0

0

0

0

0

1 (3.2)

0

 Blurred vision

1 (1.1)

0

0

0

1 (3.2)

0

0

0