Fig. 4
From: Drug-releasing mesenchymal cells strongly suppress B16 lung metastasis in a syngeneic murine model
SDF-1 expression and presence of SDF-1+ cells in the lung of mice bearing B16-melanoma metastasis. a-f Immunostaining for SDF-1 of normal and metastatic lung. In (a) normal lung parenchyma shows no staining for SDF-1 at lower (200x left panel) and at higher magnification (600x right panel). In (b) metastatic lung parenchyma shows an intense SDF-1 staining at both magnifications (200x and 600x). In (c,d) the metastatic lung shows the presence of SDF-1+ cells (white arrows) in the parenchyma near or at periphery of metastasis (m). In (e,f) high magnification of a lung metastasis (m) showing the presence of SFD-1 + cells (white arrows) and a diffuse SDF-1 staining (red arrows) along the entire border of the metastasis