Drug-releasing mesenchymal cells strongly suppress B16 lung metastasis in a syngeneic murine model

Table 1 SR4987PTX injected i.v. suppress B16 lung metastasis

Section A
Groups	days of treatments	Median number of lung metastasis (interval)	% of Metastasis inhibition
Controls (saline)	0	37 (12-60)	-
PTX (10 mg/Kg)	5,10,15	11 (11-15)*	70.3
SR4987 (10⁵)	5,10,15	40 (16-51)	0
SR4987PTX (10⁵)	5,10,15	5 (2-9)**^,°	86.5
SR4987PTX (5×10⁴)	5,10,15	3 (2-4)**^,°	91.8°
Section B
Controls (saline)	0	29 (12-32)	-
PTX (10 mg/Kg)	5,10,15	10 (9-11)*	65
SR4987PTX(5×10⁴)	5,10,15	3 (2-4)**^,°	90°

Legend. On day 0, C57Bl6 mice were injected i.v. with 2.5×10⁵/0.2 ml B16 melanoma cells On day 5, 10 and 15 after B16 injection, mice were treated i.v. with saline (controls), PTX (10 mg/Kg), SR4987(10⁵/0.2 ml) and SR4987PTX at 10⁵ and 5×10⁴/0.2 ml respectively. On day 21 after tumor cells injection, mice were sacrificed and lung nodules counted under a dissecting stereomicroscopy. Numbers in the table are the median number and the range of metastases determined for each group of mice (12) and are the media of three different experiments. * p < 0.05; ** p <0.01 vs controls; ° p < 0.05 vs PTX treated mice

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