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Table 1 SR4987PTX injected i.v. suppress B16 lung metastasis

From: Drug-releasing mesenchymal cells strongly suppress B16 lung metastasis in a syngeneic murine model

Section A
Groups days of treatments Median number of lung metastasis (interval) % of Metastasis inhibition
Controls (saline) 0 37 (12-60) -
PTX (10 mg/Kg) 5,10,15 11 (11-15)* 70.3
SR4987 (105) 5,10,15 40 (16-51) 0
SR4987PTX (105) 5,10,15 5 (2-9)**,° 86.5
SR4987PTX (5×104) 5,10,15 3 (2-4)**,° 91.8°
Section B
Controls (saline) 0 29 (12-32) -
PTX (10 mg/Kg) 5,10,15 10 (9-11)* 65
SR4987PTX(5×104) 5,10,15 3 (2-4)**,° 90°
  1. Legend. On day 0, C57Bl6 mice were injected i.v. with 2.5×105/0.2 ml B16 melanoma cells On day 5, 10 and 15 after B16 injection, mice were treated i.v. with saline (controls), PTX (10 mg/Kg), SR4987(105/0.2 ml) and SR4987PTX at 105 and 5×104/0.2 ml respectively. On day 21 after tumor cells injection, mice were sacrificed and lung nodules counted under a dissecting stereomicroscopy. Numbers in the table are the median number and the range of metastases determined for each group of mice (12) and are the media of three different experiments. * p < 0.05; ** p <0.01 vs controls; ° p < 0.05 vs PTX treated mice