Table 3 NDDIs between antineoplastic drugs and other medications

Warfarin x Capecitabine/Paclitaxel

1 (head-neck)

Decreased dosage of warfarin required owing to an increased risk of haemorrhage

Moderate

Quinolones x Cyclophosphamide

2 (breast)

Mucositis induced by anticancer agents might alter the absorption of kinolon

Minor

Ondansetron x Cisplatin^a

1 (colorectal)

Increased dosage of cisplatin required

Moderate

Warfarin x Tamoxifene

4 (breast)

Increased risk of haemorrhage probably due to decreased metabolism of warfarin

Major

Phenytoin x Cisplatin

2 (colorectal)

Increased dosage of phenytoin required

Major

Hydrochlorothiazide x 5-FU/cyclophosphamide

1 (bladder)

hydrochlorothiazide may prolong chemotherapy induced neutropenia

Moderate

Furosemide x Cisplatin

1 (colorectal)

Ototoxicity augmentation, unknown mechanism

Minor