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Table 4 nDDIs described between general and OTC medications

From: A pilot study on the impact of known drug-drug interactions in cancer patients

Interaction N. of cases Description Severity
Warfarin x corticosteroids 1 Increased or decreased in anticoagulant effect of warfarin, unknown mechanism Moderate
Proton pump inhibitors x phenytoin 2 Increased dosage of anticonvulsant required Minor
Ondansetron x Opioids 1 Severe constipation Moderate
Acetylsalicylic acid x Warfarin 4 Increased anticoagulant effect of warfarin Major
Acetylsalicylic acid x ACE inhibitors/beta-blockers 2 Lowering blood pressure effect of ACE inhibitors and beta-blockers may be reduced by prostaglandin synthesis inhibition Minor