Fig. 1From: Proton pump inhibitors for the treatment of cancer in companion animalspH regulation in cancer cells. A number of proteins and chemical reactions regulates pH in cells. The present review focuses on NHE1 and V-ATPase. 1: CAs, 2: ATP-Synthase, 3: NHE1, 4: MCTs, 5: V-H+-ATPase, 6: Cl−/HCO3 −. pHi = Intracellular pH. pHe = Extracellular pH [28]Back to article page