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Table 2 Relationships between the expression of ANXA2, HE4 and clinicopathological parameters of 84 endometrial carcinoma patients

From: Expression and clinical significance of annexin A2 and human epididymis protein 4 in endometrial carcinoma

Parameters

Cases

ANXA2

HE4

Positive exp. (%)

P-value

High exp. (%)

P-value

Positive exp. (%)

P-value

High exp. (%)

P-value

Age at diagnosis

  < 59

42

39(92.9 %)

p > 0.05

26(61.9 %)

p > 0.05

36(85.7 %)

p > 0.05

18(42.9 %)

p > 0.05

  ≥ 59

42

41(97.6 %)

29(69.0 %)

36(85.7 %)

20(47.6 %)

FIGO stage

 I

53

49(92.5 %)

p > 0.05

29(54.7 %)

p I-II/III-IV  = 0.001

45(84.9 %)

p > 0.05

20(37.7 %)

p I-II/III-IV  = 0.013

 II

7

7(100 %)

4(57.1 %)

5(71.4 %)

2(28.6 %)

 III

21

21(100 %)

19(90.5 %)

19(90.5 %)

13(61.9 %)

 IV

3

3(100 %)

3(100 %)

3(100.0 %)

3(100 %)

Pathologic type

 Endometiod

39

35(89.7 %)

p > 0.05

23(59.0 %)

p > 0.05

34(87.2 %)

p > 0.05

18(46.2 %)

p > 0.05

 Serous

19

19(100 %)

13(68.4 %)

15(78.9 %)

6(31.6 %)

 Clear cell

17

17(100 %)

12(70.6 %)

16(94.1 %)

8(47.1 %)

 Othersa

9

9(100 %)

7(77.8 %)

7(77.8 %)

6(66.7 %)

Differentiation

 Well

17

14(82.4 %)

p well/poor  = 0.020

4(23.5 %)

p well/mod. = 0.003

13(76.5 %)

p > 0.05

3(17.6 %)

p well/mod. = 0.009

 Moderate

24

23(95.8 %)

17(70.8 %)

p well/poor  < 0.001

22(91.7 %)

14(58.3 %)

p well/poor = 0.026

 Poor

43

43(100 %)

34(79.1 %)

37(86.0 %)

21(48.8 %)

ERb

 -

45

44(97.8 %)

p > 0.05

33(73.3 %)

p −/+ = 0.031

40(88.9 %)

p > 0.05

21(46.7 %)

p > 0.05

 +

27

24(88.9 %)

13(48.1 %)

22(81.5 %)

11(40.7 %)

 Unknown

12

12(100 %)

9(75.0 %)

10(83.3 %)

6(50.0 %)

PRc

 -

43

43(100 %)

p −/+  = 0.023

33(76.7 %)

p −/+ = 0.006

39(90.7 %)

p > 0.05

21(48.8 %)

p > 0.05

 +

29

25(86.2 %)

13(44.8 %)

24(82.8 %)

12(41.4 %)

 Unknown

12

12(100 %)

9(75.0 %)

9(75.0 %)

5(41.7 %)

Muscular invasion

  < 1/2

51

47(92.2 %)

p > 0.05

28(54.9 %)

p = 0.011

42(82.4 %)

p > 0.05

17(33.3 %)

p = 0.006

  ≥ 1/2

33

33(100 %)

27(81.8 %)

30(90.9 %)

21(63.6 %)

LN metastasisd

 -

50

48(96.0 %)

p > 0.05

29(58.0 %)

p −/+ = 0.003

44(88.0 %)

p > 0.05

18(36.0 %)

p −/+ = 0.016

 +

19

19(100 %)

18(94.7 %)

18(94.7 %)

13(68.4 %)

 Unknown

15

13(86.7 %)

8(53.3 %)

10(66.7 %)

7(46.7 %)

  1. a”Others” including 4 mucous carcinoma, 2 squamous carcinoma, 2 undifferentiated carcinoma, 1 small cell carcinoma
  2. b12 patients without ER detection
  3. c12 patients without PR detection
  4. d15 patients without lymphadenectomy