Fig. 4
From: Resistance to multikinase inhibitor actions mediated by insulin like growth factor-1
Effects of IGF1 receptor (IGFR1) inhibitor (GSK1838705A) on Regorafenib-mediated growth inhibition in PLC/PRF/5 cells. PLC/PRF/5 cells were cultured in 1 % FBS medium in presence of IGF1 40 ng/ml or platelet lysate corresponding to 3.75 × 107 platelets/ml, Regorafenib 5 μM and GSK1838705A 1 μM, using the conditions indicated in the graph. MTT assay was assessed after 48 h. The results of three independent experiments are expressed as mean ± SD. **p < 0.001; ***p < 0.0001