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Table 4 Univariate and multivariate for overall survival: Cox proportional hazards regression model

From: Phosphorylated AKT1 is associated with poor prognosis in esophageal squamous cell carcinoma

Prognostic factors OS
P value P value HR (95 % CI)
(univariate) (multivariate) (for multivariate)
Sex (male, female) 0.011 0.012 1.346 (1.071-1.803)
Age (≤60, >60 year) 0.373   
Tumor location (upper, middle, lower) 0.277   
Tumor length (<5 cm, ≥5 cm) 0.890   
Tumor differentiation (well, moderately, poorly) 0.148   
T stage (T1, T2, T3, T4) 0.128   
N stage (N0, N1, N2, N3) <0.001 <0.001  
N0    1
N1    1.875 (1.187–2.962)
N2    3.646 (2.355–5.645)
N3    2.444 (1.387–4.307)
Adjuvant therapy (none, chemotherapy, radiotherapy, chemoradiotherapy, unknown) 0.027   
EGFR (≥80, <80) 0.735   
p-EGFR (≥10, <10) 0.392   
AKT1 (≥30, <30) 0.362   
p-AKT1 (≥70, <70) <0.001 <0.001 2.682 (1.891–3.802)
AKT2 (>0, =0) 0.179   
p-AKT2 (>0, =0) 0.379   
ERK1 (≥40, <40) 0.683   
ERK2 (≥70, <70) 0.558   
p-ERK1/2 (≥50, <50) 0.209   
STAT3 (≥50, <50) 0.233   
p-STAT3 (≥30, <30) 0.621   
  1. HR, hazard ratio; CI, confidence interval; OS = overall survival