Table 4 Univariate and multivariate for overall survival: Cox proportional hazards regression model

Sex (male, female)

0.011

0.012

1.346 (1.071-1.803)

Age (≤60, >60 year)

0.373

Tumor location (upper, middle, lower)

0.277

Tumor length (<5 cm, ≥5 cm)

0.890

Tumor differentiation (well, moderately, poorly)

0.148

T stage (T1, T2, T3, T4)

0.128

N stage (N0, N1, N2, N3)

<0.001

<0.001

N0

1

N1

1.875 (1.187–2.962)

N2

3.646 (2.355–5.645)

N3

2.444 (1.387–4.307)

Adjuvant therapy (none, chemotherapy, radiotherapy, chemoradiotherapy, unknown)

0.027

EGFR (≥80, <80)

0.735

p-EGFR (≥10, <10)

0.392

AKT1 (≥30, <30)

0.362

p-AKT1 (≥70, <70)

<0.001

<0.001

2.682 (1.891–3.802)

AKT2 (>0, =0)

0.179

p-AKT2 (>0, =0)

0.379

ERK1 (≥40, <40)

0.683

ERK2 (≥70, <70)

0.558

p-ERK1/2 (≥50, <50)

0.209

STAT3 (≥50, <50)

0.233

p-STAT3 (≥30, <30)

0.621