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Fig. 5 | Journal of Experimental & Clinical Cancer Research

Fig. 5

From: Up-regulation of activating and inhibitory NKG2 receptors in allogeneic and autologous hematopoietic stem cell grafts

Fig. 5

Immunohistochemical staining with mAb MEM-E/02 to HLA-E. HLA-E is strongly expressed in the bone lytic localizations of a Diffuse Large B Cell Lymphoma (panel a; pt 188; score = 2), but not in a case of Hodgkin’s Lymphoma (b; pt 190; score = 0), although isolated cells with histiocytic appearance show weak cytoplasmic stain. The same case of Hodgkin Lymphoma moderately expresses ULBP-1 and ULBP-2 in Hodgkin’s cells and Reed-Sternberg cells (c and d; score = 1). Background lymphocytes moderately express ULBP-1 (c). A bone marrow biopsy of a Multiple Myeloma is strongly reactive for HLA-E (e; pt 191; score = 2), and this reactivity is enhanced and becomes highly diffuse (f; score = 3) at relapse, 880 days post-transplant. All panels FFPE tissues; 400x magnification

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