Fig. 6

a Confocal images of Colo 205 cells incubated with AuCOOH(Cy5)_ isotype (negative control) and AuCOOH(Cy5)_ mAb198.3 and nucleus stained with DAPI. Incubated time: 15 min, 30,min and 4 h. (Blue fluorescence is associated with DAPI, and red fluorescence is associated with Cy5). Scale bar at 20 μm. b Quantitative ICP-MS analysis of the number of AuCOOH, AuCOOH_isotype and AuCOOH_mAb198.3 in colo-205 cells. All of the data are reported as the means ± S.D. Comparisons were performed with a one-way analysis of variance (ANOVA) followed by Bonferroni’s multiple comparison tests using GraphPad Prism 5.01 software. Significance was defined as P < 0.0001 (***)