Fig. 5

Quantification of the amount of AuCOOH miR-218 mimics, AuCOOH_miR-218 mimics@CS and AuCOOH_miR-218 mimics@FACS present in U87MG and A549 cells. Samples were analysed by ICP-MS to determine the amount of gold in both U87MG and A549 cells after 6 h incubation with 150nM of three particles. Cellular uptake experiments with each gold nanoparticle were repeated three times, and each replicate was measured five times by ICP-MS. Error bars represent standard deviations of these measurements. Comparisons were performed with a one-way analysis of variance (ANOVA) followed by Bonferroni’s multiple comparison tests using GraphPad Prism 5.01 software. Significance was defined as P < 0.001 (**)