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Fig. 6 | Journal of Experimental & Clinical Cancer Research

Fig. 6

From: Long non-coding RNA Loc554202 induces apoptosis in colorectal cancer cells via the caspase cleavage cascades

Fig. 6

Loc554202 promotes the apoptosis of colorectal cancer cells via the caspase cleavage cascades. a HCT116 and DLD1 cells were transfected with pCDNA-Loc554202 in the presence or absence of Z-VAD-FMK (10 mmol/L) for 24 h. The apoptotic status of the cells was determined by a flowcytometric analysis. The data represent the means ± SD. * P < 0.05. b The results of the qRT-PCR analysis of caspase-3, caspase-9, Bax, and Bcl-2 after the transfection of pCDNA-Loc554202 or empty vector into HCT116 and DLD1 cells. c The results of the western blot analysis of the levels of cleaved caspase-3, cleaved caspase-9, Bax and Bcl-2 after the transfection of pCDNA-Loc554202 or empty vector into HCT116 and DLD1 cells. The GAPDH protein was used as an internal control. *P < 0.05

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