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Table 3 Univariate prognostic analysis of overall survival and disease-free survival in HCC patients

From: DDR2 facilitates hepatocellular carcinoma invasion and metastasis via activating ERK signaling and stabilizing SNAIL1

Variable n Overall survival rate (%) Disease-free survival rate (%)
3y 5y P value 3y 5y P value
Gender        
 Female 25 87.7 66.8   56.0 44.0  
 Male 87 60.9 46.4 0.100 47.1 31.8 0.234
Age (year)        
  ≤ 45 29 82.4 57.3   62.1 37.9  
  > 45 83 61.4 40.8 0.417 44.6 34.7 0.639
HBsAg statusa        
 Negative 22 90.5 85.4   72.7 59.1  
 Positive 90 61.1 41.4 0.008* 43.3 29.6 0.017*
Cirrhosis        
 No 37 64.2 58.1   51.4 39.9  
 Yes 75 68.0 47.7 0.440 48.0 33.3 0.457
AFP (μg/l)b        
  ≤ 400 55 61.3 53.4   49.1 39.7  
  > 400 57 71.9 48.7 0.699 49.1 31.6 0.714
Tumor size        
  ≤ 5 cm 37 75.7 58.9   51.4 39.9  
  > 5 cm 75 62.3 46.8 0.398 48.0 33.3 0.938
Tumor number        
 Single 86 71.8 57.1   55.8 43.9  
 Multiple 26 50.0 30.8 <0.001* 26.9 7.7 <0.001*
Tumor capsule        
 Complete 20 75.0 52.2   50.0 44.4  
 Incomplete 92 65.0 50.5 0.507 48.9 33.7 0.611
Vascular invasion        
 No 86 67.2 55.0   53.5 41.6  
 Yes 26 65.4 37.1 0.011* 34.6 15.4 0.004*
Edmondson grade        
 I/II 64 76.3 56.0   64.1 44.8  
 III/IV 48 54.2 43.7 0.027* 29.2 22.9 0.002*
TNM stage        
 I/II 67 69.8 62.0   58.2 47.5  
 III/IV 45 62.2 34.0 <0.001* 35.6 17.8 0.001*
DDR2 level        
 Low 56 83.7 66.3   69.6 53.1  
 High 56 50.0 35.7 <0.001* 28.6 17.9 <0.001*
  1. a HbsAg hepatitis B surface antigen, b AFP a-fetoprotein, *P < 0.05