DDR2 facilitates hepatocellular carcinoma invasion and metastasis via activating ERK signaling and stabilizing SNAIL1

Table 3 Univariate prognostic analysis of overall survival and disease-free survival in HCC patients

Variable	n	Overall survival rate (%)			Disease-free survival rate (%)
Variable	n	3y	5y	P value	3y	5y	P value
Gender
Female	25	87.7	66.8		56.0	44.0
Male	87	60.9	46.4	0.100	47.1	31.8	0.234
Age (year)
≤ 45	29	82.4	57.3		62.1	37.9
> 45	83	61.4	40.8	0.417	44.6	34.7	0.639
HBsAg status^a
Negative	22	90.5	85.4		72.7	59.1
Positive	90	61.1	41.4	0.008^*	43.3	29.6	0.017^*
Cirrhosis
No	37	64.2	58.1		51.4	39.9
Yes	75	68.0	47.7	0.440	48.0	33.3	0.457
AFP (μg/l)^b
≤ 400	55	61.3	53.4		49.1	39.7
> 400	57	71.9	48.7	0.699	49.1	31.6	0.714
Tumor size
≤ 5 cm	37	75.7	58.9		51.4	39.9
> 5 cm	75	62.3	46.8	0.398	48.0	33.3	0.938
Tumor number
Single	86	71.8	57.1		55.8	43.9
Multiple	26	50.0	30.8	<0.001^*	26.9	7.7	<0.001^*
Tumor capsule
Complete	20	75.0	52.2		50.0	44.4
Incomplete	92	65.0	50.5	0.507	48.9	33.7	0.611
Vascular invasion
No	86	67.2	55.0		53.5	41.6
Yes	26	65.4	37.1	0.011^*	34.6	15.4	0.004^*
Edmondson grade
I/II	64	76.3	56.0		64.1	44.8
III/IV	48	54.2	43.7	0.027^*	29.2	22.9	0.002^*
TNM stage
I/II	67	69.8	62.0		58.2	47.5
III/IV	45	62.2	34.0	<0.001^*	35.6	17.8	0.001^*
DDR2 level
Low	56	83.7	66.3		69.6	53.1
High	56	50.0	35.7	<0.001^*	28.6	17.9	<0.001^*

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