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Table 3 Top six enriched functional clusters of GO terms and KEGG pathways

From: Identification and validation of potential prognostic lncRNA biomarkers for predicting survival in patients with multiple myeloma

GO terms and KEGG pathways NO. of genes P-value Fold enrichment
Cluster 1 (Enrichment Score: 11.01)
GO:0000280 ~ nuclear division 33 4.55E-14 5.14
GO:0007067 ~ mitosis 33 4.55E-14 5.14
GO:0000279 ~ M phase 40 6.73E-14 4.16
GO:0000087 ~ M phase of mitotic cell cycle 33 7.61E-14 5.05
GO:0048285 ~ organelle fission 33 1.42E-13 4.94
GO:0022403 ~ cell cycle phase 43 1.43E-12 3.56
GO:0007049 ~ cell cycle 61 2.78E-12 2.69
GO:0000278 ~ mitotic cell cycle 39 1.25E-11 3.61
GO:0022402 ~ cell cycle process 47 2.41E-10 2.85
GO:0051301 ~ cell division 31 2.50E-09 3.60
GO:0000070 ~ mitotic sister chromatid segregation 12 3.47E-09 11.42
GO:0000819 ~ sister chromatid segregation 12 4.82E-09 11.11
GO:0007059 ~ chromosome segregation 16 9.96E-09 6.77
Cluster 2 (Enrichment Score: 4.27)
GO:0051276 ~ chromosome organization 38 8.45E-08 2.68
GO:0016568 ~ chromatin modification 19 0.001137 2.37
GO:0006325 ~ chromatin organization 23 0.001656 2.08
Cluster 3 (Enrichment Score: 3.58)
GO:0006260 ~ DNA replication 20 2.88E-06 3.61
hsa03030:DNA replication 7 9.85E-04 5.89
GO:0006261 ~ DNA-dependent DNA replication 7 0.006632 4.13
Cluster 4 (Enrichment Score: 3.33)
GO:0007051 ~ spindle organization 8 2.94E-04 6.09
GO:0000226 ~ microtubule cytoskeleton organization 14 3.64E-04 3.26
GO:0007017 ~ microtubule-based process 19 4.48E-04 2.57
GO:0007010 ~ cytoskeleton organization 26 0.001002 2.04
Cluster 5 (Enrichment Score: 2.59)
GO:0006259 ~ DNA metabolic process 34 1.31E-05 2.30
GO:0006974 ~ response to DNA damage stimulus 21 0.006553 1.93
GO:0006281 ~ DNA repair 16 0.019452 1.93
GO:0033554 ~ cellular response to stress 26 0.025459 1.57
Cluster 6 (Enrichment Score: 2.57)
GO:0008380 ~ RNA splicing 23 3.03E-05 2.77
GO:0006397 ~ mRNA processing 23 1.82E-04 2.454
GO:0016071 ~ mRNA metabolic process 24 5.39E-04 2.22
GO:0006396 ~ RNA processing 31 6.70E-04 1.94
GO:0000398 ~ nuclear mRNA splicing, via spliceosome 11 0.014111 2.46
GO:0000377 ~ RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 11 0.014111 2.46
GO:0000375 ~ RNA splicing, via transesterification reactions 11 0.014111 2.46
hsa03040:Spliceosome 10 0.022065 2.40