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Table 3 Top six enriched functional clusters of GO terms and KEGG pathways

From: Identification and validation of potential prognostic lncRNA biomarkers for predicting survival in patients with multiple myeloma

GO terms and KEGG pathways

NO. of genes

P-value

Fold enrichment

Cluster 1 (Enrichment Score: 11.01)

GO:0000280 ~ nuclear division

33

4.55E-14

5.14

GO:0007067 ~ mitosis

33

4.55E-14

5.14

GO:0000279 ~ M phase

40

6.73E-14

4.16

GO:0000087 ~ M phase of mitotic cell cycle

33

7.61E-14

5.05

GO:0048285 ~ organelle fission

33

1.42E-13

4.94

GO:0022403 ~ cell cycle phase

43

1.43E-12

3.56

GO:0007049 ~ cell cycle

61

2.78E-12

2.69

GO:0000278 ~ mitotic cell cycle

39

1.25E-11

3.61

GO:0022402 ~ cell cycle process

47

2.41E-10

2.85

GO:0051301 ~ cell division

31

2.50E-09

3.60

GO:0000070 ~ mitotic sister chromatid segregation

12

3.47E-09

11.42

GO:0000819 ~ sister chromatid segregation

12

4.82E-09

11.11

GO:0007059 ~ chromosome segregation

16

9.96E-09

6.77

Cluster 2 (Enrichment Score: 4.27)

GO:0051276 ~ chromosome organization

38

8.45E-08

2.68

GO:0016568 ~ chromatin modification

19

0.001137

2.37

GO:0006325 ~ chromatin organization

23

0.001656

2.08

Cluster 3 (Enrichment Score: 3.58)

GO:0006260 ~ DNA replication

20

2.88E-06

3.61

hsa03030:DNA replication

7

9.85E-04

5.89

GO:0006261 ~ DNA-dependent DNA replication

7

0.006632

4.13

Cluster 4 (Enrichment Score: 3.33)

GO:0007051 ~ spindle organization

8

2.94E-04

6.09

GO:0000226 ~ microtubule cytoskeleton organization

14

3.64E-04

3.26

GO:0007017 ~ microtubule-based process

19

4.48E-04

2.57

GO:0007010 ~ cytoskeleton organization

26

0.001002

2.04

Cluster 5 (Enrichment Score: 2.59)

GO:0006259 ~ DNA metabolic process

34

1.31E-05

2.30

GO:0006974 ~ response to DNA damage stimulus

21

0.006553

1.93

GO:0006281 ~ DNA repair

16

0.019452

1.93

GO:0033554 ~ cellular response to stress

26

0.025459

1.57

Cluster 6 (Enrichment Score: 2.57)

GO:0008380 ~ RNA splicing

23

3.03E-05

2.77

GO:0006397 ~ mRNA processing

23

1.82E-04

2.454

GO:0016071 ~ mRNA metabolic process

24

5.39E-04

2.22

GO:0006396 ~ RNA processing

31

6.70E-04

1.94

GO:0000398 ~ nuclear mRNA splicing, via spliceosome

11

0.014111

2.46

GO:0000377 ~ RNA splicing, via transesterification reactions with bulged adenosine as nucleophile

11

0.014111

2.46

GO:0000375 ~ RNA splicing, via transesterification reactions

11

0.014111

2.46

hsa03040:Spliceosome

10

0.022065

2.40