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Fig. 1 | Journal of Experimental & Clinical Cancer Research

Fig. 1

From: Metabolic reprogramming: the emerging concept and associated therapeutic strategies

Fig. 1

Cancer stem cells and MRD formation. Heterogeneous tumor tissue with combined-modality therapy leads to the formation of MRD, which is clinically undetectable. Transiently reduced heterogeneity is observed in MRD, which is enriched in CSCs. Relapse or metastasis results in re-acquisition of a heterogeneous population that is more potentially aggressive in terms of its degree of “stemness”

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