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Fig. 4 | Journal of Experimental & Clinical Cancer Research

Fig. 4

From: Metabolic reprogramming: the emerging concept and associated therapeutic strategies

Fig. 4

Interaction of caveolin 1-deficient CAFs with tumor cells. Cancer cells induce a pseudo-hypoxic microenvironment rich in ROS derived from metabolic reprogramming. By contrast, CAFs negative for caveolin 1 provide tumor cells with lactate, pyruvate, and ketone bodies. Notably, although cancer cells depend heavily on mitochondrial metabolism, CAFs exhibit the Warburg effect and activation of the autophagic pathway

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