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Fig. 3 | Journal of Experimental & Clinical Cancer Research

Fig. 3

From: Crizotinib-induced antitumour activity in human alveolar rhabdomyosarcoma cells is not solely dependent on ALK and MET inhibition

Fig. 3

Changes in molecular regulators of cell cycle in RH4 and RH30 cell lines treated with crizotinib. a Immunofluorescence experiments showing the expression and localization of p21, Cdc25C, Cdc2, Cyclin B1 and p-Cdc2 (Thr14/Tyr15) proteins in RH4 cells treated or not with 1.5 μM crizotinib for 24 h. b Immunofluorescence experiments showing the expression and localization of p21, Cdc25C, Cdc2, Cyclin B1 and p-Cdc2 (Thr14/Tyr15) proteins in RH30 cells treated with 1.5 μM crizotinib for 24 h. Control cells were treated with DMSO. TRITC-phalloidin was used to mark F-actin filaments of cellular cytoskeleton. Images captured under ApoTome microscope at 40× magnification

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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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