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Table 1 The average expression intensities of CMTM4 in multiple cancers

From: CMTM4 is frequently downregulated and functions as a tumour suppressor in clear cell renal cell carcinoma

Tissue

Sample size

ARS a

P-value b

Bonferroni c

bladder cancer

186

76.85

0.0068754

1

bladder control

64

68.66

  

astrocytoma

207

89.69

1.68E-12

9.18E-08

ependymoma

152

94.47

0.0024976

1

glioblastoma d

498

86.55

3.01E-28

1.65E-23

medulloblastoma d

302

77.27

8.22E-49

4.48E-44

meningioma d

89

85.75

1.69E-24

9.24E-20

neuroblastoma d

221

75.38

5.83E-47

3.18E-42

oligodendroglioma

117

87.55

7.10E-07

0.038745

retinoblastoma d

78

71.50

7.52E-29

4.11E-24

brain control

104

94.09

  

breast cancer

3080

86.27

0.0209644

1

breast control

374

85.54

  

colorectal adenocarcinoma

1841

92.80

3.59E-91

1.96E-86

colon mucosa normal

273

96.33

  

gastric cancer

681

87.53

9.01E-13

4.91E-08

gastric control

61

92.61

  

head and neck squamous cell carcinoma

220

80.40

0.0990636

1

head and neck squamous cell control

59

83.71

  

ccRCC d

652

83.83

1.58E-100

8.60E-96

kidney control

244

95.42

  

hepatocellular carcinoma

263

68.85

0.4185167

1

liver control

62

69.47

  

lung adenocarcinoma

1158

86.85

2.46E-06

0.1344489

lung squamous cell carcinoma

422

82.11

1.11E-15

6.09E-11

lung control

333

85.84

  

oral squamous cell carcinoma

339

80.12

0.0026408

1

oral squamous cell control

118

81.62

  

ovarian cancer

379

86.87

2.78E-05

1

ovary control

120

89.28

  

pancreatic cancer

263

84.44

0.0205749

1

pancreas control

83

86.73

  

prostate cancer

345

86.29

6.11E-12

3.33E-07

prostate control

81

72.88

  

skin melanoma

522

79.30

6.76E-15

3.69E-10

skin normal

305

84.12

  
  1. aARS denotes the average rank score
  2. bThe P-values were calculated using the Wilcoxon rank-sum test in the R (http://www.r-project.org/) software environment and are relative to the corresponding normal or non-tumour tissues
  3. cThe P-values were adjusted using Bonferroni correction in the function “p.adjust” in the R software
  4. dThe expression levels of CMTM4 in the underlined tissues were considered to be significantly downregulated by fully considering the differences in the ARS values, the Bonferroni correction adjusted P-values and the RBE curves shown in Fig. 1
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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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