Neuron navigator 2 overexpression indicates poor prognosis of colorectal cancer and promotes invasion through the SSH1L/cofilin-1 pathway

Table 1 Correlation between NAV2 protein expression and clinicopathological features of 138 CRC patients (cohort 1)

Clinicopathological features			NAV2 expression
Clinicopathological features		n	Low (n = 47)	High (n = 91)	P value
Age (years)	<65	67	25	42	0.433
	≥65	71	22	49
Gender	Male	80	30	50	0.316
	Female	58	17	41
Tumor location	Left colon	45	16	29	0.408
	Right colon	45	12	33
	Rectum	48	19	29
Tumor differentiation	Well-Moderate	72	24	48	0.851
	Poor	66	23	43
TNM stage	I-II	37	27	10	< 0.0001
	III-IV	101	20	81
Depth of invasion	T1-T2	43	27	16	< 0.001
	T3-T4	95	20	75
Lymph node metastasis	N0	39	23	16	0.0001
	N1-N2	99	24	75
Distant metastasis	M0	119	45	74	0.020
	M1	19	2	17
CEA	<5 ng/ml	85	31	54	0.449
	≥5 ng/ml	53	16	37
Adjuvant therapy	YES	94	35	59	0.250
	NO	44	12	32

P < 0.05 was considered statistically significant. The P values of chi-square test

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