Fig. 5

Tivantinib induces apoptosis of MHCC97L and Huh7 cells though the intrinsic and extrinsic pathway. a MHCC97L and Huh7 cells were treated with tivantinib for 48 h, and then stained with Annexin V–FITC and propidium iodide (PI) for flow cytometric analysis. Data were analyzed using Kaluza software and were reported as the mean ± SD. b Changes of the expression of apoptosis related proteins in MHCC97L and Huh7 cells treated with tivantinib for 48 h. *, P < 0.05 vs. the control group