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Table 1 Tivantinib overcome P-gp mediated MDR

From: Tivantinib induces G2/M arrest and apoptosis by disrupting tubulin polymerization in hepatocellular carcinoma

Cell lines Tivantinib IC50 (nM) Paclitaxel IC50 (nM) Vincristine IC50 (nM)
HepG2/adr 412 ± 59.6 5851 ± 52.4 3631 ± 67.8
HepG2 392 ± 48.7 15.6 ± 4.67 26.7 ± 6.23
HEK293-MDR1 327 ± 21.8 987 ± 43.8 1021 ± 92.3
HEK293-pcDNA3.1 342 ± 35.6 45.3 ± 8.54 17.1 ± 6.72
  1. Cells were treated with different concentration of tivantinib for 72 h in DMEM containing 10 % FBS. IC50 was calculated by nonlinear regression analysis using GraphPad Prism software