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Table 1 Tivantinib overcome P-gp mediated MDR

From: Tivantinib induces G2/M arrest and apoptosis by disrupting tubulin polymerization in hepatocellular carcinoma

Cell lines

Tivantinib IC50 (nM)

Paclitaxel IC50 (nM)

Vincristine IC50 (nM)

HepG2/adr

412 ± 59.6

5851 ± 52.4

3631 ± 67.8

HepG2

392 ± 48.7

15.6 ± 4.67

26.7 ± 6.23

HEK293-MDR1

327 ± 21.8

987 ± 43.8

1021 ± 92.3

HEK293-pcDNA3.1

342 ± 35.6

45.3 ± 8.54

17.1 ± 6.72

  1. Cells were treated with different concentration of tivantinib for 72 h in DMEM containing 10 % FBS. IC50 was calculated by nonlinear regression analysis using GraphPad Prism software
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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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