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Table 1 Patient characteristics and EpCAM Protein Expression by Flow Cytometry and by qReal-Time PCR in carcinosarcoma cell lines

From: Solitomab, an EpCAM/CD3 bispecific antibody construct (BiTE®), is highly active against primary uterine and ovarian carcinosarcoma cell lines in vitro

Cell Line

Histology

 

Age

Race

FIGO Stage

Primary site

Percentage EpCAM-Positive Cells

MFI

Avg dCt qReal-Time PCR

 

ES

SC

       

SARARK-1

Homologous

ESS

70

AA*

IC

Uterus

10.6

13.2

17.87

END + CC

SARARK-3

Heterologous

CDRS

75

C

IIIC

Ovary

100

726

3.84

SER

SARARK-6

Homologous

CDR

78

C

IV/IIB

Ovary

100

301.2

3.57

SER

SARARK-7

Heterologous

CDRS

55

AA

IV

Ovary

100

939.9

7.16

CC + SER

SARARK-9

Homologous

ESS

66

C

IIIC2

Uterus

100

862.6

6.05

SER

  1. *AA African-American, C Caucasian, FIGO International Federation of Gynecology and Obstetrics, EC epithelial component, SC stromal component, END endometrioid, ESS endometrial stromal sarcoma, CC clear cell, CDR chondroid, CDRS chondrosarcoma, SER serous