Fig. 1

Regorafenib dose-dependently inhibits growth of patient-derived xenografts. The effects of regorafenib 5, 10, and 15 mg/kg/day on tumor growth inhibition (a), tumor weight (b), and bodyweight (c) in xenograft model GC09-0109 are shown. Data are mean ± standard error (*, p < 0.01; **, p < 0.001; N.S., not significant)