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Table 1 Regorafenib inhibits the growth of patient-derived gastric cancer xenograft models

From: Antitumor activity of the multikinase inhibitor regorafenib in patient-derived xenograft models of gastric cancer

Xenograft model

Treatment

Mean ± SE tumor weight (g)

Tumor growth inhibition (%)a

p value versus vehicle

GC09-0109

Vehicle

1.14 (0.12)

  

Reg 5

0.21 (0.03)

81.4

<0.001

Reg 10

0.17 (0.02)

84.9

<0.001

Reg 15

0.14 (0.02)

88.1

<0.001

GC28-1107

Vehicle

1.72 (0.16)

  

Reg 5

0.48 (0.06)

72.4

<0.001

Reg 10

0.39 (0.06)

77.6

<0.001

Reg 15

0.21 (0.03)

88.0

<0.001

GC09-0109

Vehicle

0.92 (0.05)

  

Reg 10

0.14 (0.01)

84.9

<0.01

GC22-0808

Vehicle

2.55 (0.27)

  

Reg 10

0.11 (0.01)

95.9

<0.001

GC17-0409

Vehicle

2.03 (0.22)

  

Reg 10

0.36 (0.05)

82.4

<0.001

GC10-0608

Vehicle

3.11 (0.35)

  

Reg 10

0.31 (0.04)

90.0

<0.001

GC28-1107

Vehicle

1.40 (0.12)

  

Reg 10

0.40 (0.02)

71.5

<0.001

GC23-0909

Vehicle

1.73 (0.11)

  

Reg 10

0.22 (0.02)

87.0

<0.001

GC30-0309

Vehicle

3.48 (0.28)

  

Reg 10

0.59 (0.07)

83.0

<0.001

GC05-0208B

Vehicle

2.17 (0.10)

  

Reg 10

0.49 (0.03)

77.6

<0.001

  1. Reg 5: regorafenib 5 mg/kg/day; Reg 10: regorafenib 10 mg/kg/day; Reg 15: regorafenib 15 mg/kg/day
  2. aTumor growth inhibition based on the difference in tumor weight between vehicle and regorafenib