Table 2 Regorafenib 10 mg/kg/day reduces mean microvessel density, cell proliferation (p histone H3 Ser¹⁰-positive cells) and apoptosis (cleaved PARP-positive cells) in patient-derived gastric cancer xenograft models

GC09-0109

20.0 (6.0)

2.0 (0.5)*

10.0

8.3 (1.6)

2.1 (0.7)*

4.0

1.2 (0.5)

2.1 (0.6)

1.8

GC28-1107

11.4 (1.8)

2.4 (0.8)*

4.8

4.6 (0.4)

1.4 (0.6)*

3.3

0.3 (0.1)

7.3 (1.5)*

24.3

GC22-0808

23.0 (7.0)

2.1 (0.7)*

11.0

8.9 (2.1)

8.2 (1.4)

1.1

2.7 (1.5)

6.8 (2.4)*

2.5

GC30-0309

16.0 (4.0)

5.0 (2.0)*

3.2

17.8 (8.0)

5.3 (2.0)*

3.4

1.4 (0.7)

17.2 (4.0)*

12.3

GC10-0608

24.0 (5.0)

2.7 (1.0)*

8.9

10.3 (3.0)

2.1 (0.4)*

4.9

0.9 (0.4)

4.8 (1.4)*

5.3

GC17-0409

28.0 (7.0)

5.0 (1.4)*

5.6

15.3 (5.0)

4.8 (1.1)*

3.2

0.4 (0.2)

31.0 (10.0)*

77.5

GC05-0208B

43.0 (11.0)

4.0 (1.2)*

10.8

4.8 (0.9)

3.1 (0.8)

1.5

3.1 (0.9)

9.9 (3.0)*

3.2

GC23-0909

16.1 (2.8)

5.2 (1.0)*

3.1

13.9 (2.8)

5.7 (1.7)*

2.4

0.3 (0.1)

7.3 (1.9)*

24.3