Correlation between mutations and mRNA expression of APC and MUTYH genes: new insight into hereditary colorectal polyposis predisposition

Table 3 Mean and Median ASE values of cases and controls for APC c.1458C > T assay

Status	N	Mean (±SD)	Median	Min	Max	Shapiro-Wilk	Multiple comparison of Kruskall-Wallis vs control
Controls^b	68	1.25 (0.21)	1.20	0.89	1.92	0.014
APC + polyposis cases	7^a	1.20 (0.41)	1.38	0.43	1.60	0.499	0.560
APC - polyposis cases	13	1.11 (0.18)	1.11	0.83	1.51	0.682	0.029
CRC cases^b	52	1.30 (0.32)	1.28	0.68	2.46	0.041	0.350
Overall	140	1.26 (0.27)	1.22	0.43	2.46

^aCase GD41 was not considered in the table because it showed monoallelic expression
^bPreviously published [11]
Bold values indicate statistical significance

ISSN: 1756-9966