Table 3 Results of Univariate and Multivariate Analysis

HYSTOLOGY

0.44

CDI vs CLI

0.90 (0.69–1.17)

GRADING

0.001

G2 vs G1

1.45 (1.12–1.87)

0.005

G3 vs G1

1.74 (1.32–2.31)

<0.0001

ER

0.27

Pos vs neg

1.19 (0.87–1.61)

PgR

0.09

Pos vs neg

1.22 (0.97–1.53)

HER2

0.11

Pos vs neg

0.73 (0.50–1.07)

Ki67

0.01

High vs low

1.29 (1.06–1.56)

T

<0.0001

<0.0001

13–18 vs <12

1.31 (1.02–1.67)

0.03

1.10 (0.85–1.43)

0.45

19–25 vs <12

2.04 (1.60–2.60)

<0.0001

1.73 (1.34–2.23)

<0.0001

>25 vs <12

2.70 (2.10–3.48)

<0.0001

2.22 (1.70–2.90)

<0.0001

TYPE*

0.001

Multiple vs single

1.55 (1.19–2.02)

LVI

<0.0001

n.c.

Yes vs No

2.88 (2.37–3.49)

COPIES

<0.0001

Macro (>5000) vs Micro (<=5000)

3.57 (2.95–4.32)

COPIE

<0.0001

<0.0001

1500–12,000 vs <1500

2.15 (1.62–2.85)

<0.0001

2.15 (1.60–2.87)

<0.0001

12,000–111,000 vs <1500

4.26 (3.24–5.62)

<0.0001

4.14 (3.12–5.49)

<0.0001

>111,000 vs <1500

7.18 (5.46–9.45)

<0.0001

6.86 (5.18–9.01)

<0.0001

MOLECULAR SUBTYPE

0.05

Luminal A vs triple neg

1.09 (0.76–1.56)

0.64

Luminal B vs triple neg

1.39 (0.97–2.01)

0.07

Her2 vs triple neg

0.76 (0.32–1.80)

0.54