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Table 2 Univariate and multivariate analyses of factors associated with survival and recurrence

From: CXCR2–CXCL1 axis is correlated with neutrophil infiltration and predicts a poor prognosis in hepatocellular carcinoma

 

OS

RFS

 

Univariate

Multivariate

Univariate

Multivariate

Variables

P-value

HR

95 % CI

P-value

P-value

HR

95 % CI

P-value

Age (>52 vs. ≤52 years)

0.438

  

NA

0.278

  

NA

Gender (male vs. female)

0.768

  

NA

0.407

  

NA

HBsAg (positive vs. negative)

0.372

  

NA

0.065

  

NA

Cirrhosis (present vs. absent)

0.278

  

NA

0.253

  

NA

ALT (>42 vs. ≤42 U/L)

0.206

  

NA

0.779

  

NA

AST (>42 vs. ≤42 U/L)

0.001

1.416

0.948–2.116

0.089

0.013

1.228

0.883–1.709

0.222

AFP (>25 vs. ≤25 ng/ml)

0.001

1.680

1.055–2.675

0.029

0.005

1.356

0.953–1.930

0.090

Tumor size (>5 vs. ≤5 cm)

0.002

1.134

0.702–1.832

0.609

0.016

1.018

0.694–1.493

0.929

Tumor differentiation (III–IV vs. I–II)

0.153

  

NA

0.377

  

NA

Vascular invasion (present vs. absent)

<0.001

1.698

0.889–3.242

0.109

0.010

1.341

0.773–2.328

0.297

Tumor multiplicity (multiple vs. solitary)

<0.001

1.276

0.664–2.452

0.464

<0.001

1.452

0.845–2.495

0.177

TNM stage (III–IV vs. I–II)

<0.001

1.301

0.752–2.250

0.346

<0.001

1.300

0.835–2.024

0.246

BCLC stage (B–C vs. 0–A)

<0.001

1.235

0.559–2.730

0.602

<0.001

1.061

0.558–2.020

0.856

CXCR2+ NT cell (high vs. low)

0.060

  

NA

0.066

  

NA

CXCR2+ PS cell (high vs. low)

0.002

1.737

1.167–2.585

0.006

0.018

1.358

0.989–1.866

0.059

CXCR2+ IT cell (high vs. low)

0.169

  

NA

0.151

  

NA

  1. Note: The Cox proportional hazards regression model was used. Variables used in multivariate analysis were adopted by univariate analysis. Terms in italics indicate statistical significance
  2. Abbreviations: AFP alpha-fetoprotein, ALT alanine aminotransferase, AST aspartate aminotransferase, BCLC Barcelona Clinic Liver Cancer, CI confidence interval, HBsAg hepatitis B surface antigen, HR hazard ratio, NA not adopted, TNM tumor-nodes-metastasis